| Literature DB >> 15456940 |
Klaus Heese1, Masako Fujita, Hiroyasu Akatsu, Takayuki Yamamoto, Kenji Kosaka, Yasuo Nagai, Tohru Sawada.
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disorder of aging, accounting for an estimated two-thirds of all cases of senile dementia. Using bioinformatics, the yeast two-hybrid-system, reverse transcription polymerase chain reaction, and fluorescence microscopy analysis, we demonstrate here that the new putative splicing regulatory protein p18SRP is a lysine-rich zinc finger domain-containing protein that interacts with the serine-arginine (SR)-rich splicing regulatory protein SRrp86. The additional finding of its down-regulation in the brain of AD subjects points to a possible pivotal role of p18SRP in the control of cellular survival.Entities:
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Year: 2004 PMID： 15456940 DOI： 10.1385/JMN:24:2:269
Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444