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Literature DB >> 15456931

Brain injury-dependent expression of activity-dependent neuroprotective protein.

Roy Zaltzman¹, Alexander Alexandrovich, Sara M Beni, Victoria Trembovler, Esther Shohami, Illana Gozes.

Abstract

Activity-dependent neuroprotective protein (ADNP), a crucial brain development factor, contains a unique sequence, termed NAPVSIPQ, which protects mice against closed head injury (CHI). The aim of this study was to determine whether CHI affects ADNP mRNA expression in the injured brain hemisphere. Male C57JBL/6J mice were subjected to CHI. Brains were removed 5 h, 24 h, 7 d, and 29 d post-CHI. A comparison was made between ADNP mRNA in the injured versus the noninjured hemisphere using real-time polymerase chain reaction. A nonsignificant change (p >0.05) was found 5 h, 24 h, and 7 d post-CHI. However, a significant increase (p <0.05) in ADNP mRNA expression was detected in the injured cerebral hemisphere 29 d post-CHI. The data presented may be associated with ADNP's crucial involvement in brain development and response to injury.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15456931 DOI： 10.1385/JMN:24:2:181

Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444

31 in total

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Review 6. Vasoactive intestinal peptide in the immune system: potential therapeutic role in inflammatory and autoimmune diseases.

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4. Davunetide (NAP) protects the retina against early diabetic injury by reducing apoptotic death.

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Journal: J Mol Neurosci Date: 2014-02-02 Impact factor: 3.444

5. Signaling cascades involved in neuroprotection by subpicomolar pituitary adenylate cyclase-activating polypeptide 38.

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Journal: J Mol Neurosci Date: 2005 Impact factor: 3.444

6. ADNP differential nucleus/cytoplasm localization in neurons suggests multiple roles in neuronal differentiation and maintenance.

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Journal: J Mol Neurosci Date: 2008-02-20 Impact factor: 3.444