Jarad M Martin1, Sandro Porceddu, LeAnn Weih, June Corry, Lester J Peters. 1. Head and Neck Unit, Division of Radiation Oncology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia. jarad.martin@petermac.org <jarad.martin@petermac.org>
Abstract
BACKGROUND: The present paper assesses treatment outcomes in a series of 20 patients with sinonasal mucosal melanoma (SNMM) over 11 years. METHODS: All patients who presented to a single institution between 1991 and 2002 with a diagnosis of SNMM had their treatment reviewed and outcomes determined. RESULTS: Twenty patients presented to our institution with SNMM over the study period. No cervical node or metastatic involvement was detected at presentation. The most common site of involvement was the nasal cavity (17/20). The majority of patients received initial surgery followed by radiotherapy (15/20). At the completion of treatment 14 patients had no disease evident. The median time to failure in these patients was 12 months. Of these patients 10 relapsed, including six who had metastatic failure only. Fifteen patients died due to disease. Median overall survival was 17 months, with a 2-year overall survival of 23%. In univariate analysis, patients with advanced tumours (T3-4) had a 4.3 times greater risk of dying than patients with early tumours (T1-2). CONCLUSIONS: Patients with SNMM have poor outcomes with conventional therapy. Full staging prior to treatment is recommended. Aggressive treatment carrying significant morbidity is justified only for patients with early stage disease.
BACKGROUND: The present paper assesses treatment outcomes in a series of 20 patients with sinonasal mucosal melanoma (SNMM) over 11 years. METHODS: All patients who presented to a single institution between 1991 and 2002 with a diagnosis of SNMM had their treatment reviewed and outcomes determined. RESULTS: Twenty patients presented to our institution with SNMM over the study period. No cervical node or metastatic involvement was detected at presentation. The most common site of involvement was the nasal cavity (17/20). The majority of patients received initial surgery followed by radiotherapy (15/20). At the completion of treatment 14 patients had no disease evident. The median time to failure in these patients was 12 months. Of these patients 10 relapsed, including six who had metastatic failure only. Fifteen patients died due to disease. Median overall survival was 17 months, with a 2-year overall survival of 23%. In univariate analysis, patients with advanced tumours (T3-4) had a 4.3 times greater risk of dying than patients with early tumours (T1-2). CONCLUSIONS:Patients with SNMM have poor outcomes with conventional therapy. Full staging prior to treatment is recommended. Aggressive treatment carrying significant morbidity is justified only for patients with early stage disease.
Authors: K Luna-Ortiz; M Aguilar-Romero; V Villavicencio-Valencia; E Zepeda-Castilla; H Vidrio-Morgado; N Peteuil; A Mosqueda-Taylor Journal: Med Oral Patol Oral Cir Bucal Date: 2016-07-01
Authors: Alexandros Andrianakis; Peter Kiss; Markus Pomberger; Axel Wolf; Dietmar Thurnher; Peter Valentin Tomazic Journal: Wien Klin Wochenschr Date: 2021-04-12 Impact factor: 1.704