P A LoBue1, W Betancourt, L Cowan, L Seli, C Peter, K S Moser. 1. Field Services and Evaluation Branch, Division of Tuberculosis Elimination, Centers for Disease Control, Atlanta, Georgia 30333, USA. pgl5@cdc.gov
Abstract
SETTING: Local public health department. DESIGN: Retrospective review of a cluster of three pulmonary Mycobacterium bovis cases occurring in a family, with genotyping of M. bovis strains isolated from the family members. RESULTS: The genotypes of the M. bovis isolates were identical, as determined by three different methods: IS6110 restriction fragment length polymorphism, spoligoytping and mycobacterial interspersed repetitive units-variable number tandem repeat analyses. CONCLUSION: The identification of three acid-fast bacilli (AFB) smear-positive pulmonary M. bovis cases, presenting in a single family and caused by an identical strain, suggests that person-to-person transmission of this organism may have occurred, although infection of one or more family members through ingestion of a contaminated dairy product could not be excluded.
SETTING: Local public health department. DESIGN: Retrospective review of a cluster of three pulmonary Mycobacterium bovis cases occurring in a family, with genotyping of M. bovis strains isolated from the family members. RESULTS: The genotypes of the M. bovis isolates were identical, as determined by three different methods: IS6110 restriction fragment length polymorphism, spoligoytping and mycobacterial interspersed repetitive units-variable number tandem repeat analyses. CONCLUSION: The identification of three acid-fast bacilli (AFB) smear-positive pulmonary M. bovis cases, presenting in a single family and caused by an identical strain, suggests that person-to-person transmission of this organism may have occurred, although infection of one or more family members through ingestion of a contaminated dairy product could not be excluded.
Authors: Ailyn C Pérez-Osorio; David S Boyle; Zachary K Ingham; Alla Ostash; Romesh K Gautom; Craig Colombel; Yolanda Houze; Brandon T Leader Journal: J Clin Microbiol Date: 2011-12-07 Impact factor: 5.948
Authors: Timothy C Rodwell; Anokhi J Kapasi; Marisa Moore; Feliciano Milian-Suazo; Beth Harris; L P Guerrero; Kathleen Moser; Steffanie A Strathdee; Richard S Garfein Journal: Int J Infect Dis Date: 2010-04-18 Impact factor: 3.623
Authors: S Godreuil; E Jeziorski; A L Bañuls; T Fraisse; P Van de Perre; M L Boschiroli Journal: J Clin Microbiol Date: 2010-10-27 Impact factor: 5.948