[Central dopamine receptors: general considerations (Part 1)].

Specific protein G-coupled receptors mediate the effects of dopamine in its projection areas. Five dopaminergic receptors have been cloned, characterized and classified in two families, the D1-like family (D1- and D5-receptor subtypes) and the D2-like family (D2-, D3- and D4-receptor subtypes). These five dopamine receptor subtypes are characterized by their diversity in terms of transduction, distribution, pharmacology, functions, and regulation, leading to pleiotropic pathophysiological and pharmacological involvements in neuropsychiatric disorders underlain by a deregulation of the dopaminergic system.