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Literature DB >> 15454565

A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59.

Felipe Cortés-Ledesma¹, Francisco Malagón, Andrés Aguilera.

Abstract

We isolated a novel rad52 mutation, rad52-L89F, which specifically impairs recombination in rad51Delta cells. rad52-L89F displays phenotypes similar to rad59Delta and encodes a mutant protein impaired in its ability to interact with Rad59. These results support the idea that Rad59 acts in homologous recombination via physical interaction with Rad52.

Entities: Gene Mutation Species

Mesh：

Substances：

Year: 2004 PMID： 15454565 PMCID： PMC1448092 DOI： 10.1534/genetics.104.030551

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

23 in total

1. Human RAD52 exhibits two modes of self-association.

Authors: W Ranatunga; D Jackson; J A Lloyd; A L Forget; K L Knight; G E Borgstahl
Journal: J Biol Chem Date: 2001-02-13 Impact factor: 5.157

2. RAD51 is required for the repair of plasmid double-stranded DNA gaps from either plasmid or chromosomal templates.

Authors: S Bärtsch; L E Kang; L S Symington
Journal: Mol Cell Biol Date: 2000-02 Impact factor: 4.272

3. The human Rad52 protein exists as a heptameric ring.

Authors: A Z Stasiak; E Larquet; A Stasiak; S Müller; A Engel; E Van Dyck; S C West; E H Egelman
Journal: Curr Biol Date: 2000-03-23 Impact factor: 10.834

4. A novel allele of RAD52 that causes severe DNA repair and recombination deficiencies only in the absence of RAD51 or RAD59.

Authors: Y Bai; A P Davis; L S Symington
Journal: Genetics Date: 1999-11 Impact factor: 4.562

5. Yeast spt6-140 mutation, affecting chromatin and transcription, preferentially increases recombination in which Rad51p-mediated strand exchange is dispensable.

Authors: F Malagón; A Aguilera
Journal: Genetics Date: 2001-06 Impact factor: 4.562

Review 6. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae.

Authors: F Pâques; J E Haber
Journal: Microbiol Mol Biol Rev Date: 1999-06 Impact factor: 11.056

Review 7. Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair.

Authors: Lorraine S Symington
Journal: Microbiol Mol Biol Rev Date: 2002-12 Impact factor: 11.056

8. Investigation of the stability of yeast rad52 mutant proteins uncovers post-translational and transcriptional regulation of Rad52p.

Authors: Erin N Asleson; Dennis M Livingston
Journal: Genetics Date: 2003-01 Impact factor: 4.562

9. The yeast recombinational repair protein Rad59 interacts with Rad52 and stimulates single-strand annealing.

Authors: A P Davis; L S Symington
Journal: Genetics Date: 2001-10 Impact factor: 4.562

10. A molecular genetic dissection of the evolutionarily conserved N terminus of yeast Rad52.

Authors: Uffe H Mortensen; Naz Erdeniz; Qi Feng; Rodney Rothstein
Journal: Genetics Date: 2002-06 Impact factor: 4.562

14 in total

1. Rad52/Rad59-dependent recombination as a means to rectify faulty Okazaki fragment processing.

Authors: Miju Lee; Chul-Hwan Lee; Annie Albert Demin; Palinda Ruvan Munashingha; Tamir Amangyeld; Buki Kwon; Tim Formosa; Yeon-Soo Seo
Journal: J Biol Chem Date: 2014-04-07 Impact factor: 5.157

2. SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination.

Authors: Sonia Silva; Veronika Altmannova; Nadine Eckert-Boulet; Peter Kolesar; Irene Gallina; Lisa Hang; Inn Chung; Milica Arneric; Xiaolan Zhao; Line Due Buron; Uffe H Mortensen; Lumir Krejci; Michael Lisby
Journal: DNA Repair (Amst) Date: 2016-04-16

3. Rad51 protein controls Rad52-mediated DNA annealing.

Authors: Yun Wu; Noriko Kantake; Tomohiko Sugiyama; Stephen C Kowalczykowski
Journal: J Biol Chem Date: 2008-03-12 Impact factor: 5.157

4. Rad52 multimerization is important for its nuclear localization in Saccharomyces cerevisiae.

Authors: Iben Plate; Line Albertsen; Michael Lisby; Swee C L Hallwyl; Qi Feng; Changhyun Seong; Rodney Rothstein; Patrick Sung; Uffe H Mortensen
Journal: DNA Repair (Amst) Date: 2007-09-20

5. Role of the Rad52 amino-terminal DNA binding activity in DNA strand capture in homologous recombination.

Authors: Idina Shi; Swee C L Hallwyl; Changhyun Seong; Uffe Mortensen; Rodney Rothstein; Patrick Sung
Journal: J Biol Chem Date: 2009-10-06 Impact factor: 5.157

6. Rad52 phosphorylation by Ipl1 and Mps1 contributes to Mps1 kinetochore localization and spindle assembly checkpoint regulation.

Authors: Gyubum Lim; Won-Ki Huh
Journal: Proc Natl Acad Sci U S A Date: 2017-10-16 Impact factor: 11.205

10. Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication.

Authors: Felipe Cortés-Ledesma; Cristina Tous; Andrés Aguilera
Journal: Nucleic Acids Res Date: 2007-09-28 Impact factor: 16.971