| Literature DB >> 15454236 |
Wilna J Moree1, Ken-ichiro Kataoka, Michele M Ramirez-Weinhouse, Tatsuki Shiota, Minoru Imai, Masaki Sudo, Takaharu Tsutsumi, Noriaki Endo, Yumiko Muroga, Takahiko Hada, Hiroko Tanaka, Takuya Morita, Jonathan Greene, Doug Barnum, John Saunders, Yoshinori Kato, Peter L Myers, Christine M Tarby.
Abstract
Structure-activity relationships (SAR) of a weakly active class of CCR2b inhibitors were utilized to initiate a lead evolution program employing the Drug Discovery Engine. Several alternative structural series have been discovered that display nanomolar activity in the CCR2b binding and CCR2b-mediated chemotaxis assays.Entities:
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Year: 2004 PMID： 15454236 DOI： 10.1016/j.bmcl.2004.08.009
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823