Literature DB >> 15454232

Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase.

John G Cumming1, Caroline L McKenzie, Stuart G Bowden, Douglas Campbell, David J Masters, Jason Breed, Philip J Jewsbury.   

Abstract

SAR studies led to the identification of 4-(3-benzoylamino-6-methyl-anilino)quinazolines as potent and selective inhibitors of p38 MAP kinase. Further optimisation led to the identification of a series of 4-(3-benzoylamino-6-methyl-anilino)pyrimidines as potent inhibitors of the p38 MAP kinase signalling pathway in vitro and in vivo.

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Year:  2004        PMID： 15454232     DOI： 10.1016/j.bmcl.2004.08.007

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Targeting diverse signaling interaction sites allows the rapid generation of bivalent kinase inhibitors.

Authors:  Zachary B Hill; B Gayani K Perera; Simeon S Andrews; Dustin J Maly
Journal:  ACS Chem Biol       Date:  2011-12-22       Impact factor: 5.100

2.  Affinity reagents that target a specific inactive form of protein kinases.

Authors:  Pratistha Ranjitkar; Amanda M Brock; Dustin J Maly
Journal:  Chem Biol       Date:  2010-02-26

3.  Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src.

Authors:  Sanjay B Hari; B Gayani K Perera; Pratistha Ranjitkar; Markus A Seeliger; Dustin J Maly
Journal:  ACS Chem Biol       Date:  2013-10-29       Impact factor: 5.100

4.  Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation.

Authors:  Feng Ran; Wendong Li; Yi Qin; Tong Yu; Zhao Liu; Min Zhou; Cheng Liu; Tong Qiao; Xiaoqiang Li; Reda G Yousef; Ibrahim H Eissa; Mohamed M Khalifa
Journal:  Oxid Med Cell Longev       Date:  2021-10-28       Impact factor: 6.543

5.  Microwave-assisted simple synthesis of 2-anilinopyrimidines by the reaction of 2-chloro-4,6-dimethylpyrimidine with aniline derivatives.

Authors:  Cristina Campestre; György Keglevich; János Kóti; Luca Scotti; Carla Gasbarri; Guido Angelini
Journal:  RSC Adv       Date:  2020-03-25       Impact factor: 3.361

6.  Small molecule recognition of c-Src via the Imatinib-binding conformation.

Authors:  Arvin C Dar; Michael S Lopez; Kevan M Shokat
Journal:  Chem Biol       Date:  2008-10-20

7.  Red-Edge Excitation Shift Spectroscopy (REES): Application to Hidden Bound States of Ligands in Protein-Ligand Complexes.

Authors:  Md Lutful Kabir; Feng Wang; Andrew H A Clayton
Journal:  Int J Mol Sci       Date:  2021-03-04       Impact factor: 5.923
  7 in total

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