| Literature DB >> 15454223 |
Vinod R Hegde1, Haiyan Pu, Mahesh Patel, Pradip R Das, Julie Strizki, Vincent P Gullo, Chuan-Chu Chou, Alexei V Buevich, Tze-Ming Chan.
Abstract
The 70% aqueous methanol extract of the Peruvian plant Lippia alva (Verbenaceae) was found to contain three novel compounds, 1, 2, and 3, which were identified as inhibitors of the chemokine receptor CCR5. The structures of 1-3 were established based on extensive NMR studies. Compounds 1-3 inhibited CCR5 receptor signaling as measured by a calcium mobilization assay with IC(50) values of 5.5, 6.0, and 7.2 microg/mL, respectively.Entities:
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Year: 2004 PMID： 15454223 DOI： 10.1016/j.bmcl.2004.08.021
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823