| Literature DB >> 15454210 |
Zhengming Chen1, Ellen Davies, Wendy S Miller, Shen Shan, Kenneth J Valenzano, Donald J Kyle.
Abstract
Small molecule mu agonists based on the 4-phenyl piperidine scaffold were designed and synthesized to further investigate the therapeutic potential of loperamide analogs. The resulting compounds show excellent agonistic activity towards the human mu receptor with interesting SAR trends within the series.Entities:
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Year: 2004 PMID： 15454210 DOI： 10.1016/j.bmcl.2004.08.032
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823