| Literature DB >> 15454205 |
Philip Reigan1, Abdul Gbaj, Edwin Chinje, Ian J Stratford, Kenneth T Douglas, Sally Freeman.
Abstract
A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase has been designed and synthesised to introduce tumour selectivity. These prodrugs were oxidised by xanthine oxidase at C-2 and/or C-4 of the uracil ring to generate the desired TP inhibitor.Entities:
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Year: 2004 PMID： 15454205 DOI： 10.1016/j.bmcl.2004.08.036
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823