AIM: To clinically and histologically evaluate inflammatory response following rectocele repair using porcine collagen mesh. METHODS: Seventeen patients underwent rectocele repair using porcine collagen mesh. Inflammatory response was assessed by clinical and histological inflammatory grading pre- and postoperatively. Postoperative body temperature, complications and hospital stay was compared with 15 patients undergoing posterior colporraphy. RESULTS: Postoperative clinical examination did not demonstrate any inflammatory reaction. There were no significant changes in fibroblast count (P = 0.43), connective tissue density grading (P = 0.54), macrophage count (P = 0.20), inflammatory cell count (P = 0.48), total cell count (P = 0.51), or inflammatory grading (P = 0.87) postoperatively compared with preoperative values. Body temperature was significantly elevated for both the study and control group, although higher for the study group, postoperatively day 1 (P < 0.001). There were no significant differences in hospital stay and postoperative complications. CONCLUSION: Porcine collagen mesh was not associated with an adverse inflammatory response at clinical or histological evaluation and appears to be a safe material when used for rectocele repair.
AIM: To clinically and histologically evaluate inflammatory response following rectocele repair using porcine collagen mesh. METHODS: Seventeen patients underwent rectocele repair using porcine collagen mesh. Inflammatory response was assessed by clinical and histological inflammatory grading pre- and postoperatively. Postoperative body temperature, complications and hospital stay was compared with 15 patients undergoing posterior colporraphy. RESULTS: Postoperative clinical examination did not demonstrate any inflammatory reaction. There were no significant changes in fibroblast count (P = 0.43), connective tissue density grading (P = 0.54), macrophage count (P = 0.20), inflammatory cell count (P = 0.48), total cell count (P = 0.51), or inflammatory grading (P = 0.87) postoperatively compared with preoperative values. Body temperature was significantly elevated for both the study and control group, although higher for the study group, postoperatively day 1 (P < 0.001). There were no significant differences in hospital stay and postoperative complications. CONCLUSION: Porcine collagen mesh was not associated with an adverse inflammatory response at clinical or histological evaluation and appears to be a safe material when used for rectocele repair.
Authors: Daniel Altman; Tapio Väyrynen; Marie Ellström Engh; Susanne Axelsen; Christian Falconer Journal: Int Urogynecol J Pelvic Floor Dysfunct Date: 2008-06
Authors: Husam Abed; David D Rahn; Lior Lowenstein; Ethan M Balk; Jeffrey L Clemons; Rebecca G Rogers Journal: Int Urogynecol J Date: 2011-03-22 Impact factor: 2.894
Authors: Howard B Goldstein; Joseph Maccarone; Martin J Naughton; Oscar A Aguirre; Rakesh C Patel Journal: BMC Urol Date: 2010-12-13 Impact factor: 2.264
Authors: Aradhana Mehta; Rami Afshar; David L Warner; Amy Gardner; Ellen Ackerman; Jared Brandt; Kent C Sasse Journal: JSLS Date: 2017 Jan-Mar Impact factor: 2.172