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Literature DB >> 15453752

Ultrasensitive electrocatalytic DNA detection at two- and three-dimensional nanoelectrodes.

Rahela Gasparac¹, Bradford J Taft, Melissa A Lapierre-Devlin, Adam D Lazareck, Jimmy M Xu, Shana O Kelley.

Abstract

Electrochemical DNA detection systems are an attractive approach to the development of multiplexed, high-throughput DNA analysis systems for clinical and research applications. We have engineered a new class of nanoelectrode ensembles (NEEs) that constitute a useful platform for biomolecular electrochemical sensing. High-sensitivity DNA detection was achieved at oligonucleotide-functionalized NEEs using a label-free electrocatalytic assay. Attomole levels of DNA were detected using the NEEs, validating the promise of nanoarchitectures for ultrasensitive biosensing.

Entities: Chemical

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Year: 2004 PMID： 15453752 DOI： 10.1021/ja0458221

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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Cited

12 in total

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3. DNA hybridization detection with 100 zM sensitivity using piezoelectric plate sensors with an improved noise-reduction algorithm.

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4. Rapid, label-free genetic detection of enteropathogens in stool without genetic isolation or amplification.

Authors: Song Han; Mehmet C Soylu; Ceyhun E Kirimli; Wei Wu; Bhaswati Sen; Suresh G Joshi; Christopher L Emery; Giang Au; Xiaomin Niu; Richard Hamilton; Kyle Krevolin; Wei-Heng Shih; Wan Y Shih
Journal: Biosens Bioelectron Date: 2019-01-21 Impact factor: 10.618

5. Amplification-free in situ KRAS point mutation detection at 60 copies per mL in urine in a background of 1000-fold wild type.

Authors: Ceyhun E Kirimli; Wei-Heng Shih; Wan Y Shih
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10. Colorimetric TMPRSS2-ERG Gene Fusion Detection in Prostate Cancer Urinary Samples via Recombinase Polymerase Amplification.

Authors: Kevin M Koo; Eugene J H Wee; Matt Trau
Journal: Theranostics Date: 2016-06-15 Impact factor: 11.556

Ultrasensitive electrocatalytic DNA detection at two- and three-dimensional nanoelectrodes.

1. Interplay of Effective Surface Area, Mass Transport, and Electrochemical Features in Nanoporous Nucleic Acid Sensors.

2. Programming the detection limits of biosensors through controlled nanostructuring.

3. DNA hybridization detection with 100 zM sensitivity using piezoelectric plate sensors with an improved noise-reduction algorithm.

4. Rapid, label-free genetic detection of enteropathogens in stool without genetic isolation or amplification.

5. Amplification-free in situ KRAS point mutation detection at 60 copies per mL in urine in a background of 1000-fold wild type.

Review 6. Nanobiosensing with Arrays and Ensembles of Nanoelectrodes.

7. Electrically Guided DNA Immobilization and Multiplexed DNA Detection with Nanoporous Gold Electrodes.

8. Ultrasensitive norovirus detection using DNA aptasensor technology.

9. Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation.

10. Colorimetric TMPRSS2-ERG Gene Fusion Detection in Prostate Cancer Urinary Samples via Recombinase Polymerase Amplification.