| Literature DB >> 15453741 |
Michio Kurosu1, Mei-Huey Lin, Yoshito Kishi.
Abstract
The first example to couple aldehydes and 3-bromo-2-halopropenes in a catalytic asymmetric manner is reported. The coupling reaction is effected by the use of a chiral sulfonamide-Cr complex (prepared in situ from 1d, CrBr3, Fe(III) or from Co(II), Et3N, and Mn), TMSCl, and 2,6-lutidine. The method reported here is operationally simple and scalable, furnishing 3-halohomoallylic alcohols with a synthetically useful level of enantiomeric excess.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15453741 DOI： 10.1021/ja045557j
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419