| Literature DB >> 15452306 |
N C K Tan1, S E Heron, I E Scheffer, J T Pelekanos, J M McMahon, D F Vears, J C Mulley, S F Berkovic.
Abstract
Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15452306 DOI： 10.1212/01.wnl.0000137051.33486.c7
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910