AIM: The biology of colorectal hyperplastic polyps is of considerable relevance, because recent evidence suggests that under certain circumstances hyperplastic polyps may be precursors of neoplasms. The aim of this study was to assess and compare the clinical and molecular characteristics of hyperplastic polyps and neoplastic lesions removed from patients without the hyperplastic polyposis syndrome. METHODS: One hundred and twenty six patients were identified through a series of genetic epidemiological studies. Each patient had at least one neoplastic lesion and one hyperplastic polyp; there was a total of 147 hyperplastic polyps. All lesions were evaluated for K-ras mutations, loss of heterozygosity (LOH) of the adenomatous polyposis coli (APC) gene, and microsatellite instability. RESULTS: K-ras mutation was detected in 15 (10%) hyperplastic polyps, all from the rectosigmoid colon. No hyperplastic polyp had APC LOH or microsatellite instability. Patients with adenomas or carcinomas showing K-ras mutations were not more likely to have hyperplastic polyps with K-ras mutations. The average number of adenomas did not differ between those patients with hyperplastic polyps with K-ras mutations and those without K-ras mutations. There was no association between the hyperplastic polyp and the adenoma regarding the colon segments from which the two lesions were removed. CONCLUSIONS: The sporadic hyperplastic polyp is a lesion with limited molecular change and no relation to patients' neoplastic lesions.
AIM: The biology of colorectal hyperplastic polyps is of considerable relevance, because recent evidence suggests that under certain circumstances hyperplastic polyps may be precursors of neoplasms. The aim of this study was to assess and compare the clinical and molecular characteristics of hyperplastic polyps and neoplastic lesions removed from patients without the hyperplastic polyposis syndrome. METHODS: One hundred and twenty six patients were identified through a series of genetic epidemiological studies. Each patient had at least one neoplastic lesion and one hyperplastic polyp; there was a total of 147 hyperplastic polyps. All lesions were evaluated for K-ras mutations, loss of heterozygosity (LOH) of the adenomatous polyposis coli (APC) gene, and microsatellite instability. RESULTS:K-ras mutation was detected in 15 (10%) hyperplastic polyps, all from the rectosigmoid colon. No hyperplastic polyp had APC LOH or microsatellite instability. Patients with adenomas or carcinomas showing K-ras mutations were not more likely to have hyperplastic polyps with K-ras mutations. The average number of adenomas did not differ between those patients with hyperplastic polyps with K-ras mutations and those without K-ras mutations. There was no association between the hyperplastic polyp and the adenoma regarding the colon segments from which the two lesions were removed. CONCLUSIONS: The sporadic hyperplastic polyp is a lesion with limited molecular change and no relation to patients' neoplastic lesions.
Authors: M Konishi; R Kikuchi-Yanoshita; K Tanaka; M Muraoka; A Onda; Y Okumura; N Kishi; T Iwama; T Mori; M Koike; K Ushio; M Chiba; S Nomizu; F Konishi; J Utsunomiya; M Miyaki Journal: Gastroenterology Date: 1996-08 Impact factor: 22.682
Authors: K Otori; Y Oda; K Sugiyama; T Hasebe; K Mukai; T Fujii; H Tajiri; S Yoshida; S Fukushima; H Esumi Journal: Gut Date: 1997-05 Impact factor: 23.059
Authors: R A Lothe; S N Andersen; B Hofstad; G I Meling; P Peltomäki; S Heim; A Brøgger; M Vatn; T O Rognum; A L Børresen Journal: Genes Chromosomes Cancer Date: 1995-11 Impact factor: 5.006
Authors: J Jen; S M Powell; N Papadopoulos; K J Smith; S R Hamilton; B Vogelstein; K W Kinzler Journal: Cancer Res Date: 1994-11-01 Impact factor: 12.701
Authors: H Uchida; H Ando; K Maruyama; H Kobayashi; H Toda; H Ogawa; T Ozawa; Y Matsuda; H Sugimura; T Kanno; S Baba Journal: Jpn J Cancer Res Date: 1998-03
Authors: Fernando Martínez; Carlos Fernández-Martos; María Jesús Quintana; Antoni Castells; Antonio Llombart; Francisco Ińiguez; Vicente Guillem; Francisco Dasí Journal: Clin Transl Oncol Date: 2011-09 Impact factor: 3.405