| Literature DB >> 15451469 |
Wirongrong Chierakul1, Maaike de Fost, Yupin Suputtamongkol, Roongreung Limpaiboon, Arjen Dondorp, Nicholas J White, Tom van der Poll.
Abstract
Interferon (IFN)-gamma plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-gamma and IFN-gamma-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-gamma, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-alpha concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi.Entities:
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Year: 2004 PMID： 15451469 DOI： 10.1016/j.clim.2004.08.006
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969