OBJECTIVES: Hyperplastic polyposis (HP) is a poorly understood condition. The aim of this study is to describe the phenotype and the risk of cancer in HP. METHODS: Patients with HP, as defined by the WHO International Classification, were identified through the University of Utah and the Huntsman Cancer Institute databases. Family history was retrieved when possible. RESULTS: Fifteen patients were identified (10 M, 5 F) with a mean age at diagnosis of 52.6 +/- 16.4 yr (18-71). Sixty-five colonoscopies were performed (2-11 per person). A median of 90 polyps (16-210) per person and 15 polyps (range, 0-100) per procedure were reported. The median follow-up was 33 months (3-133); no cancer occurred during this period. Polyps were more frequent in the distal than the proximal colon (74%vs 26%; p < 0.001). The median polyp size was 4 mm (1-40 mm). Fifty-one hyperplastic polyps >10 mm were identified in 10 patients (38 proximal, 13 distal; p= 0.089). Forty-eight adenomas were found in 11 patients and were uniformly distributed. Serrated adenomas (n = 3) were found in one patient. A unique patient had 20 large hyperplastic polyps, 24 adenomas, 3 serrated adenomas, and 118 hyperplastic polyps. None of the patients had a first-degree relative with colon cancer. CONCLUSIONS: In HP, hyperplastic polyps are more frequently distal colonic, and vary greatly in size and number. Most patients also develop adenomas that are distributed throughout the colon. No cancers developed within 3 yr of follow-up. Colonoscopic surveillance at intervals of 1-3 yr, depending upon the number and size of both adenomatous and hyperplastic polyps, appears prudent.
OBJECTIVES:Hyperplastic polyposis (HP) is a poorly understood condition. The aim of this study is to describe the phenotype and the risk of cancer in HP. METHODS:Patients with HP, as defined by the WHO International Classification, were identified through the University of Utah and the Huntsman Cancer Institute databases. Family history was retrieved when possible. RESULTS: Fifteen patients were identified (10 M, 5 F) with a mean age at diagnosis of 52.6 +/- 16.4 yr (18-71). Sixty-five colonoscopies were performed (2-11 per person). A median of 90 polyps (16-210) per person and 15 polyps (range, 0-100) per procedure were reported. The median follow-up was 33 months (3-133); no cancer occurred during this period. Polyps were more frequent in the distal than the proximal colon (74%vs 26%; p < 0.001). The median polyp size was 4 mm (1-40 mm). Fifty-one hyperplastic polyps >10 mm were identified in 10 patients (38 proximal, 13 distal; p= 0.089). Forty-eight adenomas were found in 11 patients and were uniformly distributed. Serrated adenomas (n = 3) were found in one patient. A unique patient had 20 large hyperplastic polyps, 24 adenomas, 3 serrated adenomas, and 118 hyperplastic polyps. None of the patients had a first-degree relative with colon cancer. CONCLUSIONS: In HP, hyperplastic polyps are more frequently distal colonic, and vary greatly in size and number. Most patients also develop adenomas that are distributed throughout the colon. No cancers developed within 3 yr of follow-up. Colonoscopic surveillance at intervals of 1-3 yr, depending upon the number and size of both adenomatous and hyperplastic polyps, appears prudent.
Authors: Joanne Young; Mark Jenkins; Susan Parry; Bruce Young; Derek Nancarrow; Dallas English; Graham Giles; Jeremy Jass Journal: Gut Date: 2007-06-12 Impact factor: 23.059
Authors: Daniel L Edelstein; Marcia Cruz-Correa; Marievelisse Soto-Salgado; Jennifer E Axilbund; Linda M Hylind; Katharine Romans; Cherie Blair; Elizabeth Wiley; Anne C Tersmette; Johan A Offerhaus; Francis M Giardiello Journal: Clin Gastroenterol Hepatol Date: 2015-02-11 Impact factor: 11.382
Authors: Daniel D Buchanan; Kevin Sweet; Musa Drini; Mark A Jenkins; Aung Ko Win; Michael Gattas; Michael D Walsh; Mark Clendenning; Diane McKeone; Rhiannon Walters; Aedan Roberts; Alasdair Young; Heather Hampel; John L Hopper; Jack Goldblatt; Jill George; Graeme K Suthers; Kerry Phillips; Graeme P Young; Elizabeth Chow; Susan Parry; Sonja Woodall; Kathy Tucker; Amanda Muir; Michael Field; Sian Greening; Steven Gallinger; Jane Green; Michael O Woods; Renee Spaetgens; Albert de la Chapelle; Finlay Macrae; Neal I Walker; Jeremy R Jass; Joanne P Young Journal: Int J Colorectal Dis Date: 2010-03-06 Impact factor: 2.571
Authors: Daniel D Buchanan; Kevin Sweet; Musa Drini; Mark A Jenkins; Aung Ko Win; Dallas R English; Michael D Walsh; Mark Clendenning; Diane M McKeone; Rhiannon J Walters; Aedan Roberts; Sally-Ann Pearson; Erika Pavluk; John L Hopper; Michael R Gattas; Jack Goldblatt; Jill George; Graeme K Suthers; Kerry D Phillips; Sonja Woodall; Julie Arnold; Kathy Tucker; Amanda Muir; Michael Field; Sian Greening; Steven Gallinger; Renee Perrier; John A Baron; John D Potter; Robert Haile; Wendy Frankel; Albert de la Chapelle; Finlay Macrae; Christophe Rosty; Neal I Walker; Susan Parry; Joanne P Young Journal: PLoS One Date: 2010-07-16 Impact factor: 3.240