Literature DB >> 15447515

Solvable senescence model with positive mutations.

J B Coe1, Y Mao, M E Cates.   

Abstract

We build upon our previous analytical results for the Penna model of senescence to include positive mutations. We investigate whether a small but nonzero positive mutation rate gives qualitatively different results to the traditional Penna model in which no positive mutations are considered. We find that the high-lifespan tail of the distribution is radically changed in structure, but that there is not much effect on the bulk of the population. The mortality plateau that we found previously for a stochastic generalization of the Penna model is stable to a small positive mutation rate.

Mesh:

Year:  2004        PMID: 15447515     DOI: 10.1103/PhysRevE.70.021907

Source DB:  PubMed          Journal:  Phys Rev E Stat Nonlin Soft Matter Phys        ISSN: 1539-3755


  1 in total

1.  Stability of the analytical solution of Penna model of biological aging.

Authors:  M S Magdoń-Maksymowicz
Journal:  Theory Biosci       Date:  2008-10-22       Impact factor: 1.919

  1 in total

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