Literature DB >> 1544502

Time course of K+ current inhibition by low oxygen in chemoreceptor cells of adult rabbit carotid body. Effects of carbon monoxide.

J R López-López1, C González.   

Abstract

K+ currents recorded from adult rabbit chemoreceptor cells are reversibly inhibited on lowering the pO2 in the bathing solution. Bath application of a hypoxic TTX-containing solution revealed that inhibition of K+ current by low pO2 proceeds faster than TTX inhibition of Na+ currents, the apparent t1/2 being 3.68 and 7.14 s, respectively. Addition of carbon monoxide to the hypoxic gas mixture used to equilibrate the bathing solution reversed the inhibition of K+ currents by approx. 70%.

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Year:  1992        PMID： 1544502     DOI： 10.1016/0014-5793(92)80126-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

Review 1.  AMP-activated protein kinase and the regulation of Ca2+ signalling in O2-sensing cells.

Authors:  A Mark Evans
Journal:  J Physiol       Date:  2006-05-18       Impact factor: 5.182

Review 2.  The role of NADPH oxidase in carotid body arterial chemoreceptors.

Authors:  B Dinger; L He; J Chen; X Liu; C Gonzalez; A Obeso; K Sanders; J Hoidal; L Stensaas; S Fidone
Journal:  Respir Physiol Neurobiol       Date:  2006-12-15       Impact factor: 1.931

Review 3.  Transduction of chemostimuli by the type I carotid body cell.

Authors:  C Peers; K J Buckler
Journal:  J Membr Biol       Date:  1995-03       Impact factor: 1.843

Review 4.  Oxygen sensing and signaling: impact on the regulation of physiologically important genes.

Authors:  H Zhu; H F Bunn
Journal:  Respir Physiol       Date:  1999-04-01

5.  Chemoreceptor discharges and cytochrome redox changes of the rat carotid body: role of heme ligands.

Authors:  S Lahiri; W Ehleben; H Acker
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

6.  A possible dual site of action for carbon monoxide-mediated chemoexcitation in the rat carotid body.

Authors:  C Barbé; F Al-Hashem; A F Conway; E Dubuis; C Vandier; P Kumar
Journal:  J Physiol       Date:  2002-09-15       Impact factor: 5.182

7.  Carbon monoxide: a role in carotid body chemoreception.

Authors:  N R Prabhakar; J L Dinerman; F H Agani; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-14       Impact factor: 11.205

8.  Differential Expression of Large-Conductance Ca-Activated K Channels in the Carotid Body between DBA/2J and A/J Strains of Mice.

Authors:  Toshiki Otsubo; Eric W Kostuk; Alexander Balbir; Koichi Fujii; Machiko Shirahata
Journal:  Front Cell Neurosci       Date:  2011-10-11       Impact factor: 5.505

Review 9.  Carotid body chemoreceptors: physiology, pathology, and implications for health and disease.

Authors:  Rodrigo Iturriaga; Julio Alcayaga; Mark W Chapleau; Virend K Somers
Journal:  Physiol Rev       Date:  2021-02-11       Impact factor: 46.500

Review 10.  Oxygen-dependent regulation of ion channels: acute responses, post-translational modification, and response to chronic hypoxia.

Authors:  Hae Young Yoo; Sung Joon Kim
Journal:  Pflugers Arch       Date:  2021-06-17       Impact factor: 3.657
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