Literature DB >> 1544497

Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells.

A Najid1, A Simon, J Cook, H Chable-Rabinovitch, C Delage, A J Chulia, M Rigaud.   

Abstract

A new property of ursolic acid, lipoxygenase and cyclooxygenase inhibition, has been described in an acetone-extract of heather flowers (Calluna vulgaris) which could help explain the anti-inflammatory characteristics of this plant. In mouse peritoneal macrophages, human platelets and differentiated HL60 leukemic cells, ursolic acid, at 1 microM, blocks arachidonate metabolism.

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Year:  1992        PMID： 1544497     DOI： 10.1016/0014-5793(92)80117-y

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  Ursolic acid ameliorates Nthy-ori 3-1 cells injury induced by IL-1β through limiting MALAT1/miR-206/PTGS1 ceRNA network and NF-κB signaling pathway.

Authors:  Lunpan Mou; Liyan Liao; Yaping Zhang; Desong Ming; Jianjia Jiang
Journal:  Psychopharmacology (Berl)       Date:  2021-01-16       Impact factor: 4.530

2.  Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells.

Authors:  Rui-Xin Lin; Lu-Lu Gong; Li-Mei Fan; Zhong-Kai Zhao; Shu-Li Yang
Journal:  Int J Clin Exp Pathol       Date:  2015-02-01

3.  In vitro activity of heather [Calluna vulgaris (L.) Hull] extracts on selected urinary tract pathogens.

Authors:  Dragana M Vučić; Miroslav R Petković; Branka B Rodić-Grabovac; Olgica D Stefanović; Sava M Vasić; Ljiljana R Comić
Journal:  Bosn J Basic Med Sci       Date:  2014-11-15       Impact factor: 3.363

Review 4.  Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene.

Authors:  Mohammad Saleem
Journal:  Cancer Lett       Date:  2009-05-22       Impact factor: 8.679

5.  Anticancer effect of ursolic acid stearoyl glucoside in chemically induced hepatocellular carcinoma.

Authors:  Imran Kazmi; Anil Raj Narooka; Muhammad Afzal; Rajbala Singh; Fahad A Al-Abbasi; Aftab Ahmad; Firoz Anwar
Journal:  J Physiol Biochem       Date:  2013-03-20       Impact factor: 4.158

6.  Anti-herpes virus activities of bioactive fraction and isolated pure constituent of Mallotus peltatus: an ethnomedicine from Andaman Islands.

Authors:  Paromita Bag; Debprasad Chattopadhyay; Hemanta Mukherjee; Durbadal Ojha; Nilanjan Mandal; Mamta Chawla Sarkar; Tapan Chatterjee; Gobardhan Das; Sekhar Chakraborti
Journal:  Virol J       Date:  2012-05-24       Impact factor: 4.099

7.  Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT.

Authors:  Rahul Checker; Santosh K Sandur; Deepak Sharma; Raghavendra S Patwardhan; S Jayakumar; Vineet Kohli; Gautam Sethi; Bharat B Aggarwal; Krishna B Sainis
Journal:  PLoS One       Date:  2012-02-20       Impact factor: 3.240

8.  Ethnopharmacological in vitro studies on Austria's folk medicine--an unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs.

Authors:  Sylvia Vogl; Paolo Picker; Judit Mihaly-Bison; Nanang Fakhrudin; Atanas G Atanasov; Elke H Heiss; Christoph Wawrosch; Gottfried Reznicek; Verena M Dirsch; Johannes Saukel; Brigitte Kopp
Journal:  J Ethnopharmacol       Date:  2013-06-13       Impact factor: 4.360

9.  Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats.

Authors:  David Andersson; Yajun Cheng; Rui-Dong Duan
Journal:  J Cancer Res Clin Oncol       Date:  2007-06-29       Impact factor: 4.322

10.  Effects of Ursolic Acid and its Analogues on Soybean 15-Lipoxygenase Activity and the Proliferation Rate of A human Gastric Tumour Cell Line.

Authors:  D Es-Saady; A Najid; A Simon; Y Denizot; A J Chulia; C Delage
Journal:  Mediators Inflamm       Date:  1994       Impact factor: 4.711
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