| Literature DB >> 1544475 |
N R Brandt1, A H Caswell, J P Brunschwig, J J Kang, B Antoniu, N Ikemoto.
Abstract
The monoclonal antibody, mAb GE 4.90, raised against triadin, a 95 kDa protein of sarcoplasmic reticulum (SR), inhibits the slow phase of Ca2+ release from SR following depolarization of the T-tubule moiety of the triad. The antibody has virtually no effect on the fast phase of depolarization-induced Ca2+ release nor on caffeine-induced Ca2+ release. Since the slow phase of depolarization-induced Ca2+ release is also inhibited by dihydropyridines (DHP), these results suggest that triadin may be involved in the functional coupling between the DHP receptor and the SR Ca2+ channel.Entities:
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Year: 1992 PMID： 1544475 DOI： 10.1016/0014-5793(92)80100-u
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124