Literature DB >> 1544442

17O NMR and FT-IR study of the ionization state of peptides in aprotic solvents. Application to Leu-enkephalin.

I P Gerothanassis1, N Birlirakis, T Karayannis, V Tsikaris, M Sakarellos-Daitsiotis, C Sakarellos, B Vitoux, M Marraud.   

Abstract

The ionization state of Leu-enkephalin in DMSO and MeCN/DMSO (4/1) solution was studied by the combined use of 17O NMR and FT-IR spectroscopy. After lyophilization of an aqueous solution at nearly neutral pH, Leu-enkephalin essentially exists in the uncharged state in MeCN/DMSO (4/1) solution. In pure DMSO, only 40% of the Leu-enkephalin molecules are in the zwitterionic state under the same conditions.

Entities:  

Mesh:

Substances:

Year:  1992        PMID: 1544442     DOI: 10.1016/0014-5793(92)80053-j

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  2 in total

1.  Molecular dynamics simulations of Leu-enkephalin in water and DMSO.

Authors:  D van der Spoel; H J Berendsen
Journal:  Biophys J       Date:  1997-05       Impact factor: 4.033

2.  Exploring Conformational Preferences of Leu-enkephalin Using the Conformational Search and Double-Hybrid DFT Energy Calculations.

Authors:  Hae Sook Park; Byung Jin Byun; Young Kee Kang
Journal:  ACS Omega       Date:  2022-07-26
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.