| Literature DB >> 1544406 |
H Schooltink1, H Schmitz-Van de Leur, P C Heinrich, S Rose-John.
Abstract
The hepatic IL-6-receptor is composed of an 80 kDa IL-6-binding protein and a 130 kDa polypeptide (gp130) believed to be involved in signal transduction. Previous experiments have shown that the 80 kDa IL-6-receptor is up-regulated by glucocorticoids, but not by IL-6. Here we demonstrate that IL-6 together with the synthetic glucocorticoid dexamethasone induces the expression of mRNA for gp130 approximately 5-fold in HepG2 cells. The induction was dose- and time-dependent. Dexamethasone alone, interferon-gamma, IL-1 alpha and IL-1 beta had no effect. A possible role for the regulation of the IL-6-signal transducing protein gp130 in various inflammatory states is proposed.Entities:
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Year: 1992 PMID： 1544406 DOI： 10.1016/0014-5793(92)80552-r
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124