Literature DB >> 1544232

The structure of two IgMs showing different activity from a patient with Waldenstrom's macroglobulinaemia.

E Méndez1, C Osuna, A Sánchez, Y Revilla, F Soriano, C Montalbán, J Seguí, J Avila.   

Abstract

The two monoclonal IgMs (IgM1 and IgM2) were characterized from a patient Waldenström's macroglobulinaemia that resulted in a gammapathy. Heavy and light chains were isolated from the IgM. The complete primary structure of the two light chains and the NH2-terminal region of the two heavy chain molecules were determined. The sequence data indicated that the heavy and light chains from both IgMs belong to the same (III and II) lambda subgroups. By testing their antibody activity it was found by immunofluorescence and immunoblotting that only IgM2 reacts with an intermediate filament protein.

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Year:  1992        PMID： 1544232      PMCID： PMC1554315          DOI： 10.1111/j.1365-2249.1992.tb03022.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  21 in total

1.  Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma.

Authors:  M L Cleary; T C Meeker; S Levy; E Lee; M Trela; J Sklar; R Levy
Journal:  Cell       Date:  1986-01-17       Impact factor: 41.582

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  Monoclonal IgM with anti-muscle tissue activity in a patient with Waldenström's macroglobulinaemia: secretion of identical immunoglobulin by the established lymphoid cell line.

Authors:  C Micouin; J M Seigneurin; J C Renversez; B Roussel; M Favre; D Leroux
Journal:  Clin Exp Immunol       Date:  1984-12       Impact factor: 4.330

4.  Complete amino acid sequence of the Aspergillus cytotoxin mitogillin.

Authors:  J L Fernandez-Luna; C López-Otin; F Soriano; E Méndez
Journal:  Biochemistry       Date:  1985-02-12       Impact factor: 3.162

5.  Identity of the Fc fragments of pathological and normal human immunoglobulin M.

Authors:  G Florent; D Lehman; D Lockhart; F W Putnam
Journal:  Biochemistry       Date:  1974-07-30       Impact factor: 3.162

6.  Abnormalities in lymphocyte profile and specificity repertoire of patients with Waldenstrom's macroglobulinemia, multiple myeloma, and IgM monoclonal gammopathy of undetermined significance.

Authors:  L M Pilarski; E J Andrews; H M Serra; J A Ledbetter; B A Ruether; M J Mant
Journal:  Am J Hematol       Date:  1989-02       Impact factor: 10.047

7.  Myeloma proteins as tumor-specific transplantation antigens.

Authors:  R G Lynch; R J Graff; S Sirisinha; E S Simms; H N Eisen
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

8.  Human monoclonal IgM with autoantibody activity against intermediate filaments.

Authors:  K Dellagi; J C Brouet; J Perreau; D Paulin
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

9.  Emergence of idiotype variants during treatment of B-cell lymphoma with anti-idiotype antibodies.

Authors:  T Meeker; J Lowder; M L Cleary; S Stewart; R Warnke; J Sklar; R Levy
Journal:  N Engl J Med       Date:  1985-06-27       Impact factor: 91.245

10.  The amino acid sequence of chicken muscle desmin provides a common structural model for intermediate filament proteins.

Authors:  N Geisler; K Weber
Journal:  EMBO J       Date:  1982       Impact factor: 11.598
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