Literature DB >> 1543481

Sequences of the botulinal neurotoxin E derived from Clostridium botulinum type E (strain Beluga) and Clostridium butyricum (strains ATCC 43181 and ATCC 43755).

S Poulet1, D Hauser, M Quanz, H Niemann, M R Popoff.   

Abstract

Recently, it has been shown that two Clostridium butyricum strains (ATCC 43181 and ATCC 43755), isolated from cases of infant botulism, produce a botulinal neurotoxin type E (BoNT/E). Here we have determined the nucleotide sequences of the BoNT/E genes of these two C. butyricum strains and from C. botulinum E strain Beluga. We show that the sequences of the BoNT/E genes from the two C. butyricum strains are identical and differ in only 64 positions resulting in 39 amino acid changes (97% identity at the amino acid level) from that derived from C. botulinum. Our data suggest a transfer of the BoNT/E gene from C. botulinum to the originally nontoxigenic C. butyricum strains.

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Year:  1992        PMID： 1543481     DOI： 10.1016/0006-291x(92)91615-w

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  27 in total

1.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1992-08-25       Impact factor: 16.971

2.  Genetic diversity among Botulinum Neurotoxin-producing clostridial strains.

Authors:  K K Hill; T J Smith; C H Helma; L O Ticknor; B T Foley; R T Svensson; J L Brown; E A Johnson; L A Smith; R T Okinaka; P J Jackson; J D Marks
Journal:  J Bacteriol       Date:  2006-11-17       Impact factor: 3.490

3.  Analysis of Clostridium botulinum serotype E strains by using multilocus sequence typing, amplified fragment length polymorphism, variable-number tandem-repeat analysis, and botulinum neurotoxin gene sequencing.

Authors:  Thomas E Macdonald; Charles H Helma; Yulin Shou; Yolanda E Valdez; Lawrence O Ticknor; Brian T Foley; Stephen W Davis; George E Hannett; Cassandra D Kelly-Cirino; Jason R Barash; Stephen S Arnon; Miia Lindström; Hannu Korkeala; Leonard A Smith; Theresa J Smith; Karen K Hill
Journal:  Appl Environ Microbiol       Date:  2011-10-14       Impact factor: 4.792

4.  Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization.

Authors:  T J Smith; J Lou; I N Geren; C M Forsyth; R Tsai; S L Laporte; W H Tepp; M Bradshaw; E A Johnson; L A Smith; J D Marks
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

5.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1992-06-11       Impact factor: 16.971

6.  Tetanus neurotoxin utilizes two sequential membrane interactions for channel formation.

Authors:  Joshua R Burns; Michael R Baldwin
Journal:  J Biol Chem       Date:  2014-06-27       Impact factor: 5.157

7.  Mapping of the antibody-binding regions on botulinum neurotoxin H-chain domain 855-1296 with antitoxin antibodies from three host species.

Authors:  M Z Atassi; B Z Dolimbek; M Hayakari; J L Middlebrook; B Whitney; M Oshima
Journal:  J Protein Chem       Date:  1996-10

8.  Multiplex PCR assay for detection and identification of Clostridium botulinum types A, B, E, and F in food and fecal material.

Authors:  M Lindström; R Keto; A Markkula; M Nevas; S Hielm; H Korkeala
Journal:  Appl Environ Microbiol       Date:  2001-12       Impact factor: 4.792

9.  Botulinum type A neurotoxin digested with pepsin yields 132, 97, 72, 45, 42, and 18 kD fragments.

Authors:  J A Gimenez; B R DasGupta
Journal:  J Protein Chem       Date:  1993-06

10.  Gene probes for identification of the botulinal neurotoxin gene and specific identification of neurotoxin types B, E, and F.

Authors:  K D Campbell; M D Collins; A K East
Journal:  J Clin Microbiol       Date:  1993-09       Impact factor: 5.948
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