Literature DB >> 1541530

Cellular pertussis vaccine containing a Bordetella pertussis strain that produces a nontoxic pertussis toxin molecule.

I Marsili1, M Pizza, F Giovannoni, G Volpini, M Bartalini, R Olivieri, R Rappuoli, L Nencioni.   

Abstract

Bordetella pertussis 165-9K/129G, which produces a nontoxic form of pertussis toxin (PT), was used to prepare a whole-cell diphtheria-tetanus-pertussis (DTP) vaccine. The in vivo potency and the serological response induced by this vaccine were comparable to those of the conventional DTP vaccine which contains active PT. The toxic activities induced by PT such as leukocytosis, histamine sensitivity, and potentiation of anaphylactic reactions, which are present in the conventional DTP vaccine, were absent in the new vaccine. These results suggest that the introduction of a whole-cell vaccine containing B. pertussis 165-9K/129G would induce the same immunity as the conventional vaccine and would avoid the administration of a harmful toxin to children.

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Year:  1992        PMID： 1541530      PMCID： PMC257606          DOI： 10.1128/iai.60.3.1150-1155.1992

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  24 in total

1.  Mutants of pertussis toxin suitable for vaccine development.

Authors:  M Pizza; A Covacci; A Bartoloni; M Perugini; L Nencioni; M T De Magistris; L Villa; D Nucci; R Manetti; M Bugnoli
Journal:  Science       Date:  1989-10-27       Impact factor: 47.728

2.  A Table Determining L.D.50 or the Fifty Per Cent End-Point.

Authors:  J Worcester; E B Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1943-07       Impact factor: 11.205

3.  Phase I clinical trial of an acellular pertussis vaccine composed of genetically detoxified pertussis toxin combined with FHA and 69 kDa.

Authors:  A Podda; L Nencioni; I Marsili; S Peppoloni; G Volpini; D Donati; A Di Tommaso; M T De Magistris; R Rappuoli
Journal:  Vaccine       Date:  1991-10       Impact factor: 3.641

4.  'Pertussis vaccine encephalopathy': it is time to recognize it as the myth that it is.

Authors:  J D Cherry
Journal:  JAMA       Date:  1990 Mar 23-30       Impact factor: 56.272

5.  Characterization of genetically inactivated pertussis toxin mutants: candidates for a new vaccine against whooping cough.

Authors:  L Nencioni; M Pizza; M Bugnoli; T De Magistris; A Di Tommaso; F Giovannoni; R Manetti; I Marsili; G Matteucci; D Nucci
Journal:  Infect Immun       Date:  1990-05       Impact factor: 3.441

6.  Role of pertussigen (pertussis toxin) on the mouse protective activity of vaccines made from Bordetella species.

Authors:  J J Munoz; M G Peacock
Journal:  Microbiol Immunol       Date:  1989       Impact factor: 1.955

7.  Pertussis toxin is required for pertussis vaccine encephalopathy.

Authors:  L Steinman; A Weiss; N Adelman; M Lim; R Zuniga; J Oehlert; E Hewlett; S Falkow
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

8.  Risk of seizures and encephalopathy after immunization with the diphtheria-tetanus-pertussis vaccine.

Authors:  M R Griffin; W A Ray; E A Mortimer; G M Fenichel; W Schaffner
Journal:  JAMA       Date:  1990 Mar 23-30       Impact factor: 56.272

9.  ADP-ribosyltransferase activity of pertussis toxin and immunomodulation by Bordetella pertussis.

Authors:  W J Black; J J Munoz; M G Peacock; P A Schad; J L Cowell; J J Burchall; M Lim; A Kent; L Steinman; S Falkow
Journal:  Science       Date:  1988-04-29       Impact factor: 47.728

10.  Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT-9K/129G.

Authors:  A Podda; L Nencioni; M T De Magistris; A Di Tommaso; P Bossù; S Nuti; P Pileri; S Peppoloni; M Bugnoli; P Ruggiero
Journal:  J Exp Med       Date:  1990-09-01       Impact factor: 14.307
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  6 in total

1.  Role of pertussis toxin A subunit in neutrophil migration and vascular permeability.

Authors:  G A Brito; M H Souza; A A Melo-Filho; E L Hewlett; A A Lima; C A Flores; R A Ribeiro
Journal:  Infect Immun       Date:  1997-03       Impact factor: 3.441

2.  Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination.

Authors:  S Donnelly; C E Loscher; M A Lynch; K H Mills
Journal:  Infect Immun       Date:  2001-07       Impact factor: 3.441

3.  Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin.

Authors:  J T Barbieri; D Armellini; J Molkentin; R Rappuoli
Journal:  Infect Immun       Date:  1992-12       Impact factor: 3.441

4.  Depression of liver metabolism and induction of cytokine release by diphtheria and tetanus toxoids and pertussis vaccines: role of Bordetella pertussis cells in toxicity.

Authors:  G Fantuzzi; M Sironi; R Delgado; L Cantoni; M Rizzardini; M Carelli; I Marsili; P Ghiara; P Ghezzi
Journal:  Infect Immun       Date:  1994-01       Impact factor: 3.441

5.  Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules.

Authors:  R F Bargatze; E C Butcher
Journal:  J Exp Med       Date:  1993-07-01       Impact factor: 14.307

6.  Biology of chemokine and classical chemoattractant receptors: differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells.

Authors:  J J Campbell; S Qin; K B Bacon; C R Mackay; E C Butcher
Journal:  J Cell Biol       Date:  1996-07       Impact factor: 10.539
  6 in total

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