Literature DB >> 1541403

Promoter for the human ferritin heavy chain-encoding gene (FERH): structural and functional characterization.

M A Bevilacqua1, M Giordano, P D'Agostino, C Santoro, F Cimino, F Costanzo.   

Abstract

We conducted a functional analysis of the promoter for the human ferritin heavy chain-encoding gene (pFERH) in HepG2 and HeLa cells. The activity of pFERH is equivalent in both cell types, despite their different ferritin (Fer) isotypes. Transfections of a series of 5'-deletion mutants indicate that pFERH activity is essentially dependent on two motifs. One of them, accounting for about 50% of the total transcriptional activity, is recognized by the RNA polymerase II transcription factor, Sp1, and the other by a low-affinity factor present in both the cell types analyzed.

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Year:  1992        PMID： 1541403     DOI： 10.1016/0378-1119(92)90696-m

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  10 in total

1.  An alternative model of H ferritin promoter transactivation by c-Jun.

Authors:  Maria C Faniello; Giuseppa Chirico; Barbara Quaresima; Giovanni Cuda; Giovanna Allevato; Maria A Bevilacqua; Francesco Baudi; Vittorio Colantuoni; Filiberto Cimino; Salvatore Venuta; Vittorio E Avvedimento; Francesco Costanzo
Journal:  Biochem J       Date:  2002-04-01       Impact factor: 3.857

2.  Transcriptional regulation of the ferritin heavy-chain gene: the activity of the CCAAT binding factor NF-Y is modulated in heme-treated Friend leukemia cells and during monocyte-to-macrophage differentiation.

Authors:  G Marziali; E Perrotti; R Ilari; U Testa; E M Coccia; A Battistini
Journal:  Mol Cell Biol       Date:  1997-03       Impact factor: 4.272

3.  Ferritin H induction by histone deacetylase inhibitors.

Authors:  Wei Wang; Xiumin Di; Suzy V Torti; Frank M Torti
Journal:  Biochem Pharmacol       Date:  2010-04-10       Impact factor: 5.858

4.  Transcriptional activation of the H-ferritin gene in differentiated Caco-2 cells parallels a change in the activity of the nuclear factor Bbf.

Authors:  M A Bevilacqua; M C Faniello; P D'Agostino; B Quaresima; M T Tiano; S Pignata; T Russo; F Cimino; F Costanzo
Journal:  Biochem J       Date:  1995-11-01       Impact factor: 3.857

Review 5.  Regulation of neuronal ferritin heavy chain, a new player in opiate-induced chemokine dysfunction.

Authors:  Anna Cook Abt; Olimpia Meucci
Journal:  J Neuroimmune Pharmacol       Date:  2011-04-05       Impact factor: 4.147

6.  Functional analysis of the promoter of the mitochondrial phosphate carrier human gene: identification of activator and repressor elements and their transcription factors.

Authors:  Vito Iacobazzi; Vittoria Infantino; Paola Costanzo; Paola Izzo; Ferdinando Palmieri
Journal:  Biochem J       Date:  2005-11-01       Impact factor: 3.857

7.  P/CAF/p300 complex binds the promoter for the heavy subunit of ferritin and contributes to its tissue-specific expression.

Authors:  M A Bevilacqua; M C Faniello; T Russo; F Cimino; F Costanzo
Journal:  Biochem J       Date:  1998-11-01       Impact factor: 3.857

8.  An Sp1 binding site and the minimal promoter contribute to overexpression of the cytokeratin 18 gene in tumorigenic clones relative to that in nontumorigenic clones of a human carcinoma cell line.

Authors:  M Gunther; T Frebourg; M Laithier; N Fossar; M Bouziane-Ouartini; C Lavialle; O Brison
Journal:  Mol Cell Biol       Date:  1995-05       Impact factor: 4.272

9.  PCR-based profiling of transcription factor activity in vivo by a virus-based reporter battery.

Authors:  Hitomi Abe; Kentaro Abe
Journal:  iScience       Date:  2022-02-14

10.  Caffeine Positively Modulates Ferritin Heavy Chain Expression in H460 Cells: Effects on Cell Proliferation.

Authors:  Fabiana Zolea; Flavia Biamonte; Anna Martina Battaglia; Maria Concetta Faniello; Giovanni Cuda; Francesco Costanzo
Journal:  PLoS One       Date:  2016-09-22       Impact factor: 3.240
  10 in total

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