Literature DB >> 1540560

The chemoattractant activity of the vitreous to human scleral fibroblasts following retinal detachment and proliferative vitreoretinopathy.

N Wilson-Holt1, P Khaw, F Savage, I Grierson.   

Abstract

The results are presented of a migration assay of scleral fibroblasts to 25% diluted vitreous samples from 27 patients with complex retinal detachments divided into three groups: group 1, no proliferative vitreoretinopathy (PVR); group 2, early PVR; and group 3, advanced PVR. There was a statistically significantly greater migration with vitreous samples from group 3 than with group 1 (p less than 0.0001) but no significant correlation for migration with the age of patients, duration of retinal detachment, or number of retinal procedures undertaken. Analysis of vitreous by gel electrophoresis showed that cellular migration was proportional to the number of peptide bands. Vitreous fibronectin levels were measured and there was a positive correlation between fibronectin in the vitreous samples and the migration of fibroblasts to the vitreous (r = 0.68, p less than 0.004).

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Year:  1992        PMID： 1540560      PMCID： PMC504195          DOI： 10.1136/bjo.76.3.159

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  24 in total

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Journal:  Arch Ophthalmol       Date:  1985-05

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Journal:  Am J Ophthalmol       Date:  1977-09       Impact factor: 5.258

6.  Vitreous aspirates from patients with proliferative vitreoretinopathy stimulate retinal pigment epithelial cell migration.

Authors:  P A Campochiaro; J A Jerdan; B M Glaser; A Cardin; R G Michels
Journal:  Arch Ophthalmol       Date:  1985-09

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Authors:  R L Avery; B M Glaser
Journal:  Arch Ophthalmol       Date:  1986-08

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Authors:  M Cowley; B P Conway; P A Campochiaro; D Kaiser; H Gaskin
Journal:  Arch Ophthalmol       Date:  1989-08

9.  The significance of fibronectin in vitreoretinal pathology. A critical evaluation.

Authors:  M Weller; P Wiedemann; K Heimann; K Zilles
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1988       Impact factor: 3.117

10.  Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment.

Authors:  A E Postlethwaite; J Keski-Oja; G Balian; A H Kang
Journal:  J Exp Med       Date:  1981-02-01       Impact factor: 14.307
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  2 in total

Review 1.  Proliferative vitreoretinopathy.

Authors:  P K Leaver
Journal:  Br J Ophthalmol       Date:  1995-10       Impact factor: 4.638

2.  The significance of vitronectin in proliferative diabetic retinopathy.

Authors:  P Esser; M Bresgen; M Weller; K Heimann; P Wiedemann
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1994-08       Impact factor: 3.117
  2 in total

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