Literature DB >> 1540404

Glucosidase inhibitors for treatment of HIV-1 infection.

L Ratner1.   

Abstract

The HIV-1 envelope protein is a glycoprotein composed of 120 kD and 41 kD subunits. It contains 30-38 potential asparagine-linked glycosylation sites which have been shown to play a role in CD4 binding, virus uptake, and cytopathogenicity. Several inhibitors of oligosaccharide attachment or modification have been tested. An agent which inhibits glucosidases, N-butyl deoxynojirimycin was found to inhibit HIV-1 and SIVmac infectivity, and is currently in clinical trials.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1540404     DOI： 10.1089/aid.1992.8.165

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  7 in total

1.  Identification of two N-linked glycosylation sites within the core of the simian immunodeficiency virus glycoprotein whose removal enhances sensitivity to soluble CD4.

Authors:  Cheryl Pikora; Christine Wittish; Ronald C Desrosiers
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

2.  Resistance of native, oligomeric envelope on simian immunodeficiency virus to digestion by glycosidases.

Authors:  R E Means; R C Desrosiers
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

Review 3.  Antiviral therapy in human immunodeficiency virus infections. Current status (Part II).

Authors:  E Sandström; B Oberg
Journal:  Drugs       Date:  1993-05       Impact factor: 9.546

Review 4.  The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.

Authors:  S Bour; R Geleziunas; M A Wainberg
Journal:  Microbiol Rev       Date:  1995-03

Review 5.  Pathogenesis of human immunodeficiency virus infection.

Authors:  J A Levy
Journal:  Microbiol Rev       Date:  1993-03

6.  Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.

Authors:  E Fenouillet; I Jones; B Powell; D Schmitt; M P Kieny; J C Gluckman
Journal:  J Virol       Date:  1993-01       Impact factor: 5.103

7.  Relationship of human immunodeficiency virus type 1 sequence heterogeneity to stage of disease.

Authors:  T McNearney; Z Hornickova; R Markham; A Birdwell; M Arens; A Saah; L Ratner
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.