Literature DB >> 15389997

Bent knees and tiptoeing: late manifestations of end-stage Parkinson's disease.

Ruth Djaldetti1, Mark Hellmann, Eldad Melamed.   

Abstract

We describe a unique gait phenomenon of bent knees in 9 patients with idiopathic Parkinson disease (mean age, 73.1 +/- 11.1 years), 3 of whom also manifested tiptoeing. The bent-knee posture appeared only during ambulation; in the recumbent position, full or nearly full extension was possible in all patients. The abnormality emerged after long-standing disease (6-23 years from onset) and failed to respond to dopaminergic treatment. Most of the patients also had bent spine (camptocormia). The pathogenesis of these phenomena are unknown, but they might represent a rare type of dystonia.

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Year:  2004        PMID: 15389997     DOI: 10.1002/mds.20187

Source DB:  PubMed          Journal:  Mov Disord        ISSN: 0885-3185            Impact factor:   10.338


  8 in total

Review 1.  Toxicological and pathophysiological roles of reactive oxygen and nitrogen species.

Authors:  Ruth A Roberts; Robert A Smith; Stephen Safe; Csaba Szabo; Ronald B Tjalkens; Fredika M Robertson
Journal:  Toxicology       Date:  2010-07-17       Impact factor: 4.221

Review 2.  Camptocormia in Parkinson's disease.

Authors:  Eldad Melamed; Ruth Djaldetti
Journal:  J Neurol       Date:  2006-12       Impact factor: 4.849

3.  Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis.

Authors:  David L Carbone; Katriana A Popichak; Julie A Moreno; Stephen Safe; Ronald B Tjalkens
Journal:  Mol Pharmacol       Date:  2008-10-07       Impact factor: 4.436

4.  Reversible Pisa syndrome in patients with Parkinson's disease on dopaminergic therapy.

Authors:  Antonino Cannas; Paolo Solla; Gianluca Floris; Paolo Tacconi; Alessandra Serra; Mario Piga; Francesco Marrosu; Maria Giovanna Marrosu
Journal:  J Neurol       Date:  2009-03-18       Impact factor: 4.849

Review 5.  The chaperone Grp78 in protein folding disorders of the nervous system.

Authors:  Julie A Moreno; Evelyn Tiffany-Castiglioni
Journal:  Neurochem Res       Date:  2014-08-09       Impact factor: 3.996

6.  Progressive Worsening of Gait and Motor Abnormalities in Older Adults With Dravet Syndrome.

Authors:  Arunan Selvarajah; Carolina Gorodetsky; Paula Marques; Quratulain Zulfiqar Ali; Anne T Berg; Alfonso Fasano; Danielle M Andrade
Journal:  Neurology       Date:  2022-04-13       Impact factor: 11.800

7.  Forward flexion of trunk in Parkinson's disease patients is affected by subjective vertical position.

Authors:  Kyohei Mikami; Makoto Shiraishi; Tsubasa Kawasaki; Tsutomu Kamo
Journal:  PLoS One       Date:  2017-07-10       Impact factor: 3.240

8.  Postural abnormality as a risk marker for leg deep venous thrombosis in Parkinson's disease.

Authors:  Kazushi Yamane; Fumiharu Kimura; Kiichi Unoda; Takafumi Hosokawa; Takahiko Hirose; Hiroki Tani; Yoshimitsu Doi; Simon Ishida; Hideto Nakajima; Toshiaki Hanafusa
Journal:  PLoS One       Date:  2013-07-02       Impact factor: 3.240

  8 in total

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