Literature DB >> 15389897

Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS.

Chengyun Zheng1, Inger Nennesmo, Bengt Fadeel, Jan-Inge Henter.   

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with the death of motor neurons in the spinal cord and brainstem. The cause of ALS is unknown and there is no cure. This study demonstrates, for the first time, that vascular endothelial growth factor (VEGF) delays progression of symptoms and prolongs survival in a Cu/Zn superoxide dismutase (SOD1) transgenic mouse model of ALS. These observations suggest that VEGF or related compounds, might be of value in the treatment of ALS patients.

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Year:  2004        PMID： 15389897     DOI： 10.1002/ana.20223

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  39 in total

Review 1.  Motor neuron trophic factors: therapeutic use in ALS?

Authors:  Thomas W Gould; Ronald W Oppenheim
Journal:  Brain Res Rev       Date:  2010-10-21

Review 2.  Retrograde axonal transport and motor neuron disease.

Authors:  Anna-Lena Ström; Jozsef Gal; Ping Shi; Edward J Kasarskis; Lawrence J Hayward; Haining Zhu
Journal:  J Neurochem       Date:  2008-04-01       Impact factor: 5.372

3.  Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress.

Authors:  Shuping Li; Jinghao Sheng; Jamie K Hu; Wenhao Yu; Hiroko Kishikawa; Miaofen G Hu; Kaori Shima; David Wu; Zhengping Xu; Winnie Xin; Katherine B Sims; John E Landers; Robert H Brown; Guo-fu Hu
Journal:  Angiogenesis       Date:  2012-11-10       Impact factor: 9.596

4.  Spinal vascular endothelial growth factor induces phrenic motor facilitation via extracellular signal-regulated kinase and Akt signaling.

Authors:  Erica A Dale-Nagle; Irawan Satriotomo; Gordon S Mitchell
Journal:  J Neurosci       Date:  2011-05-25       Impact factor: 6.167

5.  Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice.

Authors:  Yaoming Wang; Xiao Ou Mao; Lin Xie; Surita Banwait; Hugo H Marti; David A Greenberg; Kunlin Jin
Journal:  J Neurosci       Date:  2007-01-10       Impact factor: 6.167

6.  Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system.

Authors:  Mary Emmanouil; Era Taoufik; Vivian Tseveleki; Sotiris-Spyros Vamvakas; Theodore Tselios; Michael Karin; Hans Lassmann; Lesley Probert
Journal:  J Immunol       Date:  2009-12-15       Impact factor: 5.422

7.  Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity.

Authors:  James C Dodge; Amanda M Haidet; Wendy Yang; Marco A Passini; Mark Hester; Jennifer Clarke; Eric M Roskelley; Christopher M Treleaven; Liza Rizo; Heather Martin; Soo H Kim; Rita Kaspar; Tatyana V Taksir; Denise A Griffiths; Seng H Cheng; Lamya S Shihabuddin; Brian K Kaspar
Journal:  Mol Ther       Date:  2008-04-01       Impact factor: 11.454

8.  Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model.

Authors:  Dan Krakora; Patrick Mulcrone; Michael Meyer; Christina Lewis; Ksenija Bernau; Genevieve Gowing; Chad Zimprich; Patrick Aebischer; Clive N Svendsen; Masatoshi Suzuki
Journal:  Mol Ther       Date:  2013-05-28       Impact factor: 11.454

Review 9.  Targeting angiogenin in therapy of amyotropic lateral sclerosis.

Authors:  Hiroko Kishikawa; David Wu; Guo-fu Hu
Journal:  Expert Opin Ther Targets       Date:  2008-10       Impact factor: 6.902

10.  Neuroprotective and Angiogenic Effects of Bone Marrow Transplantation Combined With Granulocyte Colony-Stimulating Factor in a Mouse Model of Amyotrophic Lateral Sclerosis.

Authors:  Yasuyuki Ohta; Makiko Nagai; Kazunori Miyazaki; Nobuhito Tanaka; Hiromi Kawai; Takafumi Mimoto; Nobutoshi Morimoto; Tomoko Kurata; Yoshio Ikeda; Tohru Matsuura; Koji Abe
Journal:  Cell Med       Date:  2011-10-01
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