Literature DB >> 15388975

Effects of green tea polyphenol on cognitive and acetylcholinesterase activities.

Hye Kyung Kim1, Mija Kim, Sunki Kim, Mujo Kim, Joo Ho Chung.   

Abstract

The effect of tea polyphenol (TP) on cognitive and anti-cholinesterase activity was examined in scopolamine-treated mice. Chronic administration of TP significantly reversed scopolamine-induced retention deficits in both step-through passive avoidance and spontaneous alternation behavior tasks. Furthermore, TP exhibited a dramatic inhibitory effect on acetylcholinesterase activity. This finding suggests that TP might be useful in the treatment of Alzheimer's disease.

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Year:  2004        PMID： 15388975     DOI： 10.1271/bbb.68.1977

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  15 in total

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Review 7.  Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer's disease.

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