Literature DB >> 15388470

Alterations of penicillin-binding proteins 1A, 2X, and 2B in Streptococcus pneumoniae isolates for which amoxicillin MICs are higher than penicillin MICs.

K Kosowska1, M R Jacobs, S Bajaksouzian, L Koeth, P C Appelbaum.   

Abstract

Penicillin-binding proteins (PBPs) of 15 selected penicillin- and amoxicillin-resistant Streptococcus pneumoniae isolates (MICs of 2 to 8 and 8 to 16 microg/ml, respectively) were studied. In addition to typical changes in PBPs 1A and 2X, these strains had 10 unique changes in PBP 2B, including a (618)A-G substitution, which may be the key alteration associated with amoxicillin resistance.

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Year:  2004        PMID： 15388470      PMCID： PMC521876          DOI： 10.1128/AAC.48.10.4020-4022.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Emergence in france of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin.

Authors:  C Doit; C Loukil; F Fitoussi; P Geslin; E Bingen
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

2.  Molecular epidemiological survey of penicillin-resistant Streptococcus pneumoniae from Asia, Europe, and North America.

Authors:  T Davies; R V Goering; M Lovgren; J A Talbot; M R Jacobs; P C Appelbaum
Journal:  Diagn Microbiol Infect Dis       Date:  1999-05       Impact factor: 2.803

3.  Diversity of substitutions within or adjacent to conserved amino acid motifs of penicillin-binding protein 2X in cephalosporin-resistant Streptococcus pneumoniae isolates.

Authors:  Y Asahi; Y Takeuchi; K Ubukata
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

4.  Alterations in PBP 1A essential-for high-level penicillin resistance in Streptococcus pneumoniae.

Authors:  A M Smith; K P Klugman
Journal:  Antimicrob Agents Chemother       Date:  1998-06       Impact factor: 5.191

5.  Bacteriologic and clinical efficacy of high dose amoxicillin/clavulanate in children with acute otitis media.

Authors:  R Dagan; A Hoberman; C Johnson; E L Leibovitz; A Arguedas; F V Rose; B R Wynne; M R Jacobs
Journal:  Pediatr Infect Dis J       Date:  2001-09       Impact factor: 2.129

6.  Activities of faropenem, an oral beta-lactam, against recent U.S. isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.

Authors:  Ian A Critchley; James A Karlowsky; Deborah C Draghi; Mark E Jones; Clyde Thornsberry; Kate Murfitt; Daniel F Sahm
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

7.  Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 oral antimicrobial agents based on pharmacodynamic parameters: 1997 U.S. Surveillance study.

Authors:  M R Jacobs; S Bajaksouzian; A Zilles; G Lin; G A Pankuch; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  1999-08       Impact factor: 5.191

8.  Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci.

Authors:  Kensuke Nagai; Todd A Davies; Michael R Jacobs; Peter C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

9.  Acquisition of five high-Mr penicillin-binding protein variants during transfer of high-level beta-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae.

Authors:  R Hakenbeck; A König; I Kern; M van der Linden; W Keck; D Billot-Klein; R Legrand; B Schoot; L Gutmann
Journal:  J Bacteriol       Date:  1998-04       Impact factor: 3.490

10.  Analysis of penicillin-binding protein genes of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to amoxicillin.

Authors:  Mignon du Plessis; Edouard Bingen; Keith P Klugman
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191
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  17 in total

1.  Comparative antipneumococcal activities of sulopenem and other drugs.

Authors:  Klaudia Kosowska-Shick; Lois M Ednie; Pamela McGhee; Peter C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  2009-03-23       Impact factor: 5.191

Review 2.  Variations in amoxicillin pharmacokinetic/pharmacodynamic parameters may explain treatment failures in acute otitis media.

Authors:  Michael E Pichichero; Michael D Reed
Journal:  Paediatr Drugs       Date:  2009       Impact factor: 3.022

3.  Commensal streptococci serve as a reservoir for β-lactam resistance genes in Streptococcus pneumoniae.

Authors:  Anders Jensen; Oskar Valdórsson; Niels Frimodt-Møller; Susan Hollingshead; Mogens Kilian
Journal:  Antimicrob Agents Chemother       Date:  2015-04-06       Impact factor: 5.191

4.  Molecular detection and genotypic characterisation of Streptococcus pneumoniae isolated from children in Malaysia.

Authors:  Shu Ling Goh; Boon Pin Kee; Kartini Abdul Jabar; Kek Heng Chua; Anna Marie Nathan; Jessie Bruyne; Soo Tein Ngoi; Cindy Shuan Ju Teh
Journal:  Pathog Glob Health       Date:  2020-01-31       Impact factor: 2.894

5.  Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae.

Authors:  K Kosowska-Shick; P L McGhee; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  2010-03-01       Impact factor: 5.191

6.  Expansion and evolution of the Streptococcus pneumoniae Spain9V-ST156 clonal complex in Poland.

Authors:  Ewa Sadowy; Alicja Kuch; Marek Gniadkowski; Waleria Hryniewicz
Journal:  Antimicrob Agents Chemother       Date:  2010-03-01       Impact factor: 5.191

7.  Comparative Genomic Analysis of Streptococcus pneumoniae Strains: Penicillin Non-susceptible Multi-drug-Resistant Serotype 19A Isolates.

Authors:  Lifeng Li; Juanjuan Zhou; Mingchao Li; Zengyuan Yu; Kaijie Gao; Junwen Yang; Ping Cheng; Junmei Yang; Wancun Zhang; Zhidan Yu; Huiqing Sun
Journal:  Curr Microbiol       Date:  2022-01-04       Impact factor: 2.188

8.  Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities.

Authors:  Klaudia Kosowska-Shick; Pamela McGhee; Peter C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  2009-02-23       Impact factor: 5.191

9.  Molecular characteristics of penicillin-binding protein 2b, 2x and 1a sequences in Streptococcus pneumoniae isolates causing invasive diseases among children in Northeast China.

Authors:  X Zhou; J Liu; Z Zhang; Y Liu; Y Wang; Y Liu
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2016-03-14       Impact factor: 3.267

10.  In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae.

Authors:  Lesley McGee; Donald Biek; Yigong Ge; Magderie Klugman; Mignon du Plessis; Anthony M Smith; Bernard Beall; Cynthia G Whitney; Keith P Klugman
Journal:  Antimicrob Agents Chemother       Date:  2008-11-17       Impact factor: 5.191
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