Literature DB >> 15388343

Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides.

Hedvig Tordai1, László Patthy.   

Abstract

Analysis of the exon-intron structures of 2208 human genes has revealed that there is a statistically highly significant excess of phase 1 introns in the vicinity of the signal peptide cleavage sites. It is suggested that amino acid sequences surrounding signal peptide cleavage sites are significantly enriched in phase 1 proto-splice sites and this has favored insertion of spliceosomal introns in these sites.

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Year:  2004        PMID： 15388343     DOI： 10.1016/j.febslet.2004.08.045

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

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