Literature DB >> 15387664

A cytotoxic cyclic heptapeptide from the seeds of Annona cherimola.

Alassane Wélé1, Yanjun Zhang, Idrissa Ndoye, Jean-Paul Brouard, Jean-Louis Pousset, Bernard Bodo.   

Abstract

From a methanol extract of the seeds of Annona cherimola, a new cyclic heptapeptide, cherimolacyclopeptide C, has been isolated. The structure was elucidated on the basis of the MS/MS fragmentation using a Q-TOF mass spectrometer equipped with an ESI source, extensive 2D NMR experiments, and chemical degradation. Cherimolacyclopeptide C exhibited significant in vitro cytotoxic activity against KB cells, with an IC(50) value of 0.072 microM.

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Year:  2004        PMID： 15387664     DOI： 10.1021/np040068i

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

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  8 in total

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