| Literature DB >> 15387656 |
Honglei Zhou1, Atsuko Hamazaki, Jose Domingos Fontana, Hironobu Takahashi, Tomoyuki Esumi, Carolina Bueno Wandscheer, Hiroaki Tsujimoto, Yoshiyasu Fukuyama.
Abstract
A methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Parana, Brazil, afforded seven new ring C-seco limonoids (1-7) together with three known limonoids (8-10). The structures of the new compounds were elucidated by NMR and MS analysis and comparison of spectral data with those of previously known compounds. Compounds 4 and 5 exhibited significant inhibitory activity against HeLa S3 cancer cells, whereas 1, 2, 3, and 8 showed weak cytotoxicity.Entities:
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Year: 2004 PMID： 15387656 DOI： 10.1021/np040077r
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050