Literature DB >> 15387527

One-pot homolytic aromatic substitutions/HWE olefinations under microwave conditions for the formation of a small oxindole library.

Antje Teichert1, Katja Jantos, Klaus Harms, Armido Studer.   

Abstract

[reaction: see text] An efficient one-pot sequence comprising a homolytic aromatic substitution followed by an ionic Horner-Wadsworth-Emmons olefination for the preparation of a small library of alpha,beta-unsaturated oxindoles is presented. Microwave-induced heating is used to conduct these reactions. The homolytic aromatic substitution is mediated by the persistent radical effect.

Entities:  

Year:  2004        PMID： 15387527     DOI： 10.1021/ol048759t

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  10 in total

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8.  Oxindole synthesis via polar-radical crossover of ketene-derived amide enolates in a formal [3 + 2] cycloaddition.

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9.  Direct synthesis of amides and imines by dehydrogenative homo or cross-coupling of amines and alcohols catalyzed by Cu-MOF.

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  10 in total

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