OBJECTIVE: To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection. METHODS: One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP. RESULTS: The frequency of alleles B*07, Bx 35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects. CONCLUSION: HLA-B*46 may be associated with its susceptibility to HIV-1 infections.
OBJECTIVE: To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection. METHODS: One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP. RESULTS: The frequency of alleles B*07, Bx 35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infectedpersons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects. CONCLUSION:HLA-B*46 may be associated with its susceptibility to HIV-1 infections.
Authors: Wei Song; Dongning He; Ilene Brill; Rakhi Malhotra; Joseph Mulenga; Susan Allen; Eric Hunter; Jianming Tang; Richard A Kaslow Journal: PLoS One Date: 2011-08-17 Impact factor: 3.240
Authors: Rachel D Schrier; Saurabh Gupta; Patricia Riggs; Lucette A Cysique; Scott Letendre; Hua Jin; Stephen A Spector; Kumud K Singh; Tanya Wolfson; Zunyou Wu; Kun Xue Hong; Xin Yu; Chuan Shi; Robert K Heaton Journal: PLoS One Date: 2012-05-31 Impact factor: 3.240