Filtering strategies in mass population screening for colorectal cancer: an economic evaluation.

On the basis of clinical trial data, 13 strategies for initial screening (filtering) for colorectal cancer are modeled for the purpose of economic evaluation. A wide range of detection cost estimates are generated, although ranking options by detection cost ignores the important consideration of undetected cancers. Formulating the problem as one of cost-effectiveness, however, allows the authors to demonstrate that members of a subset of strategies uniquely outperform all others and that the optimum strategy can be identified by the ex ante specification of the valuation of cancers missed on screening.