Literature DB >> 15385525

The extracellular adherence protein from Staphylococcus aureus inhibits neutrophil binding to endothelial cells.

Axana Haggar1, Cecilia Ehrnfelt, Jan Holgersson, Jan-Ingmar Flock.   

Abstract

Extracellular adherence protein (Eap) from Staphylococcus aureus inhibits the adherence of neutrophils to nonstimulated and tumor necrosis factor alpha-stimulated endothelial cells in both static adhesion assays and flow adhesion assays. Consequently, Eap also impaired their transendothelial migration. During an S. aureus infection, Eap may thus serve to reduce inflammation by inhibiting neutrophil adhesion and extravasation.

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Year:  2004        PMID: 15385525      PMCID: PMC517550          DOI: 10.1128/IAI.72.10.6164-6167.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  21 in total

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6.  Porcine endothelium activated by anti-alpha-GAL antibody binding mediates increased human neutrophil adhesion under flow.

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  10 in total

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