Literature DB >> 15385523

A calcium-calmodulin antagonist blocks experimental Vibrio vulnificus cytolysin-induced lethality in an experimental mouse model.

Young-Rae Lee1, Kwang-Hyun Park, Zhao-Zhen Lin, Young-Jong Kho, Jin-Woo Park, Hye-Won Rho, Bon-Sun Koo, Hyung-Rho Kim, Eun-Kyung Song, Hong-Nu Yu, Myung-Kwan Han, Seung-Ok Lee, Eun-Chung Jhee, Jong-Suk Kim.   

Abstract

We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.

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Year:  2004        PMID： 15385523      PMCID： PMC517569          DOI： 10.1128/IAI.72.10.6157-6159.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

1.  Isolation and characterization of a Vibrio vulnificus mutant deficient in both extracellular metalloprotease and cytolysin.

Authors:  J J Fan; C P Shao; Y C Ho; C K Yu; L I Hor
Journal:  Infect Immun       Date:  2001-09       Impact factor: 3.441

2.  Mechanism for selectively inhibiting the activation of cyclic nucleotide phosphodiesterase and adenylate cyclase by antipsychotic agents.

Authors:  B Weiss; R M Levin
Journal:  Adv Cyclic Nucleotide Res       Date:  1978

3.  Detection of anti-Vibrio vulnificus cytolysin antibodies in sera from mice and a human surviving V. vulnificus disease.

Authors:  L D Gray; A S Kreger
Journal:  Infect Immun       Date:  1986-03       Impact factor: 3.441

4.  Damage of cellular functions by trifluoperazine, a calmodulin-specific drug.

Authors:  M Osborn; K Weber
Journal:  Exp Cell Res       Date:  1980-12       Impact factor: 3.905

5.  Metalloprotease is not essential for Vibrio vulnificus virulence in mice.

Authors:  C P Shao; L I Hor
Journal:  Infect Immun       Date:  2000-06       Impact factor: 3.441

6.  Halophilic Vibrio species isolated from blood cultures.

Authors:  D G Hollis; R E Weaver; C N Baker; C Thornsberry
Journal:  J Clin Microbiol       Date:  1976-04       Impact factor: 5.948

Review 7.  Vibrio vulnificus infection: clinical manifestations, pathogenesis, and antimicrobial therapy.

Authors:  Shyh-Ren Chiang; Yin-Ching Chuang
Journal:  J Microbiol Immunol Infect       Date:  2003-06       Impact factor: 4.399

8.  Disease caused by a marine Vibrio. Clinical characteristics and epidemiology.

Authors:  P A Blake; M H Merson; R E Weaver; D G Hollis; P C Heublein
Journal:  N Engl J Med       Date:  1979-01-04       Impact factor: 91.245

9.  Vibrio vulnificus cytolysin induces hyperadhesiveness of pulmonary endothelial cells for neutrophils through endothelial P-selectin: a mechanism for pulmonary damage by Vibrio vulnificus cytolysin.

Authors:  Byeong-Soo Kim; Jong-Suk Kim
Journal:  Exp Mol Med       Date:  2002-09-30       Impact factor: 8.718

10.  Extracellular phospholipase A2 and lysophospholipase produced by Vibrio vulnificus.

Authors:  J Testa; L W Daniel; A S Kreger
Journal:  Infect Immun       Date:  1984-08       Impact factor: 3.441
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  1 in total

Review 1.  Vibrio vulnificus Hemolysin: Biological Activity, Regulation of vvhA Expression, and Role in Pathogenesis.

Authors:  Yuan Yuan; Zihan Feng; Jinglin Wang
Journal:  Front Immunol       Date:  2020-10-23       Impact factor: 7.561
  1 in total

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