| Literature DB >> 15384226 |
Antje Ostareck-Lederer1, Dirk H Ostareck.
Abstract
Studies on the post-transcriptional regulation of gene expression in haematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. HnRNP K and hnRNP E1/E2 share a common structural motif, the hnRNP K homology (KH) domain, which provides a structural basis for mRNA binding. The KH-domains are components of a modular system, which enables these proteins to engage in both, protein/nucleic acid and protein/protein interactions, the latter generating connectivity to cell signalling events. As components of different mRNA-protein complexes, hnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability in haematopoietic cell differentiation.Entities:
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Year: 2004 PMID： 15384226 DOI： 10.1016/j.biolcel.2004.03.010
Source DB: PubMed Journal: Biol Cell ISSN： 0248-4900 Impact factor: 4.458