| Literature DB >> 1538303 |
C A McDermott1, A L Kowalczyk, E R Schnitzler, H H Mangurten, K A Rodvold, S Metrick.
Abstract
Pharmacokinetic data were evaluated in 10 term neonates with seizures after intravenous administration of lorazepam, 0.05 mg/kg or 0.1 mg/kg. All seizure activity ceased, with no adverse effects. Pharmacokinetic data revealed a decreased volume of distribution and clearance, and a prolonged half-life in comparison with data from older children and adults. These findings are consistent with physiologic differences in the neonate.Entities:
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Year: 1992 PMID： 1538303 DOI： 10.1016/s0022-3476(05)80925-4
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406