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Literature DB >> 15381755

Why calcium-stimulated adenylyl cyclases?

Abstract

The Ca(2+)/calmodulin-stimulated adenylyl cyclases, AC1 and AC8, play a critical role in several forms of neuroplasticity, including long-lasting long-term potentiation (L-LTP) and long-term memory (LTM). By coupling neuronal activity and Ca(2+) increases to the production of cAMP, AC1 and AC8 activate cAMP-dependent signal transduction and transcriptional pathways critical for L-LTP and LTM.

Entities: Chemical Gene

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Year: 2004 PMID： 15381755 DOI： 10.1152/physiol.00010.2004

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

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Cited

54 in total

1. Adenylate cyclase 1 promotes strengthening and experience-dependent plasticity of whisker relay synapses in the thalamus.

Authors: Hao Wang; Hong Liu; Daniel R Storm; Zhong-wei Zhang
Journal: J Physiol Date: 2011-09-19 Impact factor: 5.182

2. The calmodulin-stimulated adenylate cyclase ADCY8 sets the sensitivity of zebrafish retinal axons to midline repellents and is required for normal midline crossing.

Authors: Hong Xu; Sarah G Leinwand; Alison L Dell; Emma Fried-Cassorla; Jonathan A Raper
Journal: J Neurosci Date: 2010-05-26 Impact factor: 6.167

Review 3. Plasticity and second messengers during synapse development.

Authors: Leslie C Griffith; Vivian Budnik
Journal: Int Rev Neurobiol Date: 2006 Impact factor: 3.230

4. Intrinsic neuronal excitability is reversibly altered by a single experience in fear conditioning.

Authors: Bridget M McKay; Elizabeth A Matthews; Fernando A Oliveira; John F Disterhoft
Journal: J Neurophysiol Date: 2009-09-02 Impact factor: 2.714

5. Beta-adrenergic receptor activation during distinct patterns of stimulation critically modulates the PKA-dependence of LTP in the mouse hippocampus.

Authors: Jennifer N Gelinas; Gustavo Tenorio; Neal Lemon; Ted Abel; Peter V Nguyen
Journal: Learn Mem Date: 2008-04-25 Impact factor: 2.460

Why calcium-stimulated adenylyl cyclases?

1. Adenylate cyclase 1 promotes strengthening and experience-dependent plasticity of whisker relay synapses in the thalamus.

2. The calmodulin-stimulated adenylate cyclase ADCY8 sets the sensitivity of zebrafish retinal axons to midline repellents and is required for normal midline crossing.

Review 3. Plasticity and second messengers during synapse development.

4. Intrinsic neuronal excitability is reversibly altered by a single experience in fear conditioning.

5. Beta-adrenergic receptor activation during distinct patterns of stimulation critically modulates the PKA-dependence of LTP in the mouse hippocampus.

Review 6. Linking neural activity and molecular oscillations in the SCN.

7. Direct demonstration of discrete Ca2+ microdomains associated with different isoforms of adenylyl cyclase.

8. Genetic disruptions of Drosophila Pavlovian learning leave extinction learning intact.

9. Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability.

10. Early calcium increase triggers the formation of olfactory long-term memory in honeybees.