Daphne E Hemmings1, D Scott Johnson, Gail T Tominaga, Jan H Wong. 1. Department of Surgery, John A. Burns School of Medicine and the Prevention and Control Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu 96813, USA.
Abstract
HYPOTHESIS: Cutaneous melanoma in nonwhite persons has a manifestation and a prognosis that are different than those of cutaneous melanoma in white persons. DESIGN: Case series. SETTING: Tertiary care university-affiliated community medical center located in a multiethnic state in which white persons are a minority of the population. PATIENTS: Consecutive series of 357 patients with melanoma seen between January 1994 and August 2003. MAIN OUTCOME MEASURES: Ethnicity, age, sex, primary site, tumor thickness, nodal status, stage at diagnosis, and survival. RESULTS: There were 208 men and 149 women who ranged in age from 15 to 93 years (mean, 58 years). Twenty-two patients initially had unknown primary sites. Of these 357 patients, 67 (18.7%) were nonwhite. There was no statistically significant difference in the age (P =.10) or sex (P =.57) distribution of these 2 populations. Nonwhite patients at initial diagnosis had thicker tumors (P =.002), more frequently had ulcerated primary tumors (P<.001), more frequently had positive nodes (P =.004), and were at a more advanced stage (P =.002) than their white counterparts. The anatomic distribution between the 2 populations was significantly different (P<.001), with a high incidence of melanoma on the sole and subungual locations and a substantially less frequent occurrence on the head and neck, trunk, and extremities in the nonwhite population when compared with the white population. The overall survival rate of the nonwhite patients was significantly worse than that of the white patients, but when stratified by stage at initial diagnosis, there was no difference in outcome. CONCLUSIONS: In a multiethnic population, cutaneous melanoma in nonwhite persons is unusual but not rare. Although the diagnoses are distinctly different at initial examinations, suggesting a potential biological component, stage-for-stage outcomes are similar between white and nonwhite persons and suggest a need for early diagnostic interventions with unusual pigmented lesions in nonwhite persons.
HYPOTHESIS: Cutaneous melanoma in nonwhite persons has a manifestation and a prognosis that are different than those of cutaneous melanoma in white persons. DESIGN: Case series. SETTING: Tertiary care university-affiliated community medical center located in a multiethnic state in which white persons are a minority of the population. PATIENTS: Consecutive series of 357 patients with melanoma seen between January 1994 and August 2003. MAIN OUTCOME MEASURES: Ethnicity, age, sex, primary site, tumor thickness, nodal status, stage at diagnosis, and survival. RESULTS: There were 208 men and 149 women who ranged in age from 15 to 93 years (mean, 58 years). Twenty-two patients initially had unknown primary sites. Of these 357 patients, 67 (18.7%) were nonwhite. There was no statistically significant difference in the age (P =.10) or sex (P =.57) distribution of these 2 populations. Nonwhite patients at initial diagnosis had thicker tumors (P =.002), more frequently had ulcerated primary tumors (P<.001), more frequently had positive nodes (P =.004), and were at a more advanced stage (P =.002) than their white counterparts. The anatomic distribution between the 2 populations was significantly different (P<.001), with a high incidence of melanoma on the sole and subungual locations and a substantially less frequent occurrence on the head and neck, trunk, and extremities in the nonwhite population when compared with the white population. The overall survival rate of the nonwhite patients was significantly worse than that of the white patients, but when stratified by stage at initial diagnosis, there was no difference in outcome. CONCLUSIONS: In a multiethnic population, cutaneous melanoma in nonwhite persons is unusual but not rare. Although the diagnoses are distinctly different at initial examinations, suggesting a potential biological component, stage-for-stage outcomes are similar between white and nonwhite persons and suggest a need for early diagnostic interventions with unusual pigmented lesions in nonwhite persons.
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