| Literature DB >> 15381118 |
Walter Magliani1, Stefania Conti, Antonella Salati, Simona Vaccari, Lara Ravanetti, Domenico L Maffei, Luciano Polonelli.
Abstract
This review focuses on the potential of yeast killer toxin (KT)-like antibodies (KTAbs), that mimic a wide-spectrum KT through interaction with specific cell wall receptors (KTR) and their molecular derivatives (killer mimotopes), as putative new tools for transdisease anti-infective therapy. KTAbs are produced during the course of experimental and natural infections caused by KTR-bearing micro-organisms. They have been produced by idiotypic vaccination with a KT-neutralizing mAb, also in their monoclonal and recombinant formats. KTAbs and KTAbs-derived mimotopes may exert a strong therapeutic activity against mucosal and systemic infections caused by eukaryotic and prokaryotic pathogenic agents, thus representing new potential wide-spectrum antibiotics.Entities:
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Year: 2004 PMID： 15381118 DOI： 10.1016/j.femsyr.2004.06.010
Source DB: PubMed Journal: FEMS Yeast Res ISSN： 1567-1356 Impact factor: 2.796