| Literature DB >> 15381010 |
Peter C Healy1, Ailsa Hocking, Nai Tran-Dinh, John I Pitt, Roger G Shivas, Jennifer K Mitchell, Mike Kotiw, Rohan A Davis.
Abstract
Chemical investigations of a microfungus Xylaria sp. isolated from the Australian rainforest tree Glochidion ferdinandi have afforded two new natural products, 2-hydroxy-6-methyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (1) and 2-hydroxy-6-hydroxymethyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (2). Compound 1 has previously been synthesised but only partially characterised. Methylation of 1 using diazomethane afforded the crystalline compound 2,8-dimethoxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester (3), whose structure was determined by single crystal X-ray analysis. This paper reports the full spectroscopic characterisation of compounds 1-3 by NMR, UV, IR and MS data. All compounds were inactive in a brine shrimp lethality assay and several antimicrobial screens.Entities:
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Year: 2004 PMID： 15381010 DOI： 10.1016/j.phytochem.2004.07.019
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072