| Literature DB >> 15380349 |
Donna E Hogge1, Michaela Feuring-Buske, Brigitte Gerhard, Arthur E Frankel.
Abstract
Addition of cytosine arabinoside (Ara-C) to truncated diphtheria toxin (DT388) fused to granulocyte macrophage-colony stimulating factor (GMCSF) or interleukin-3 (IL3) was studied in a NOD/SCID mouse model of human AML. Ara-C alone did not reduce the % human AML cells in mouse bone marrow (BM). DT388IL3 or DT388GMCSF alone reduced but did not eradicate engraftment for two of four and two of three samples, respectively. In contrast, Ara-C with DT388IL3 eliminated AML from mouse BM with one of four samples while DT388GMCSF with Ara-C eliminated or reduced AML cells as compared to mice receiving either agent alone with two of three samples.Entities:
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Year: 2004 PMID： 15380349 DOI： 10.1016/j.leukres.2004.03.015
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156