Literature DB >> 15380200

5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.

Richard Sulsky1, Jeffrey A Robl, Scott A Biller, Thomas W Harrity, John Wetterau, Fergal Connolly, Kern Jolibois, Lori Kunselman.   

Abstract

5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2-dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide.

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Year:  2004        PMID： 15380200     DOI： 10.1016/j.bmcl.2004.07.069

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Pd(OAc)(2)-catalyzed Domino reactions of 1-chloro-2-haloarenes and 2-haloaryl tosylates with hindered Grignard reagents via palladium-associated arynes.

Authors:  Cheng-Guo Dong; Qiao-Sheng Hu
Journal:  Org Lett       Date:  2006-10-26       Impact factor: 6.005

2.  Pd(OAc)(2)-catalyzed domino reactions of 1,2-dihaloarenes and 2-haloaryl arenesulfonates with Grignard reagents: efficient synthesis of substituted fluorenes.

Authors:  Cheng-Guo Dong; Qiao-Sheng Hu
Journal:  Tetrahedron       Date:  2008-03-10       Impact factor: 2.457

3.  Application of the Nested Enzyme-Within-Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects.

Authors:  Hiroyuki Takita; Adam S Darwich; Amais Ahmad; Amin Rostami-Hodjegan
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2020-09-28
  3 in total

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